ArticleFrontiers in nutrition2022
Effects of Diosmin on Vascular Leakage and Inflammation in a Mouse Model of Venous Obstruction.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- A Systematic Review: Quercetin-Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability.International journal of molecular sciences · 2024Pooled it
- The improvement of diosmin dissolution by PLGA complexes for oral delivery: physicochemical characterization and anti-inflammatory evaluation.RSC advances · 2026Article
- An inflammatory and quiescent HSC subpopulation expands with age in humans.Genome biology · 2026Article
- Pharmacological Mechanisms of Phytochemicals and Pharmaceutical Agents in Protecting Against Methotrexate-Induced Liver Injury.Oxidative medicine and cellular longevity · 2026Review
- Endothelial activation during the diapedesis of cancer cells: between the kiss of death and therapeutic breakthrough.Cellular & molecular biology letters · 2025Review
- Effective Determination of Diosmin Using Nitrogen Doped Carbon Dots as Probe Based on Internal Filtering Effect.Journal of fluorescence · 2025Review
- Efficacy and mechanism of escin in improving the tissue microenvironment of blood vessel walls via anti-inflammatory and anticoagulant effects: Implications for clinical practice.Open life sciences · 2025Review
- Diosmin ameliorates inflammation, apoptosis and activates PI3K/AKT pathway in Alzheimer's disease rats.Metabolic brain disease · 2024Article
- Diosmin: A promising phytochemical for functional foods, nutraceuticals and cancer therapy.Food science & nutrition · 2024Review
- Flavonoids as Aglycones in Retaining Glycosidase-Catalyzed Reactions: Prospects for Green Chemistry.Journal of agricultural and food chemistry · 2023Review
- Lipopolysaccharide Exacerbates Ketamine-Induced Psychotic-Like Behavior, Oxidative Stress, and Neuroinflammation in Mice: Ameliorative Effect of Diosmin.Journal of molecular neuroscience : MN · 2023Article
- An Oxygen Supply Strategy for Sonodynamic Therapy in Tuberculous Granuloma Lesions Using a Catalase-Loaded Nanoplatform.International journal of nanomedicine · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At present, iliac vein compression syndrome (IVCS) plagues countless people, posing a significant economic and social burden. The progress of current IVCS-related research is slow owing to the limitations of animal models. In this study, we generated a mouse model of iliac vein stenosis (IVS) to monitor the effects of IVCS on venous function, such as increased vascular leakage, the expression of adhesion molecules, and elevated inflammation factors. Diosmin, a widely used clinical bioactive ingredient, was administered to confirm its therapeutic effects on the IVS mouse model. The results revealed that diosmin manifested therapeutic improvement in the IVS mouse model. In addition, we verified that the IVS mouse model is a stable and reproducible animal model for pathophysiological studies. High-purity diosmin can be beneficial to venous dysfunction and hence provides a more effective treatment option for venous diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.