ArticleFrontiers in cellular and infection microbiology2022
A Mouse Periodontitis Model With Humanized Oral Bacterial Community.
Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Development of Biocompatible Fatty Acid-Based Ionic Liquids for the Effective Topical Treatment of Periodontitis.ACS omega · 2026Article
- Advances in oral disease models: a mini-review of developments from 2015 to 2025.Frontiers in dental medicine · 2026Review
- B10 cell-induced PD-L1/PD-1-linked macrophage polarization in periodontitis.Journal of translational internal medicine · 2025Article
- Human calculus adhesive-induced periodontitis model recapitulating human periodontitis microbiota in rats.BMC oral health · 2025Article
- Organoid in dentistry: Models for oral biology and disease.Journal of dental sciences · 2025Review
- Bioinspired hydrogel for sustained minocycline release: A superior periodontitis solution.Materials today. Bio · 2025Article
- Periodontal diseases in Africa.Periodontology 2000 · 2025Review
- Periodontitis aggravates pulmonary fibrosis byFrontiers in cellular and infection microbiology · 2025Article
- Single-Cell and Spatial Multi-Omics Analysis Reveal That Targeting JAG1 in Epithelial Cells Reduces Periodontal Inflammation and Alveolar Bone Loss.International journal of molecular sciences · 2024Article
- The oral-gut microbiome axis in health and disease.Nature reviews. Microbiology · 2024Review
- The Role of Macrophage Death in Periodontitis: A Review.Inflammation · 2024Review
- A Flagellin-Adjuvanted Trivalent Mucosal Vaccine Targeting Key Periodontopathic Bacteria.Vaccines · 2024Article
- The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis.Nature communications · 2024Article
- Periodontitis exacerbates pulmonary hypertension by promoting IFNγInternational journal of oral science · 2024Article
- Recombinant neutralizing secretory IgA antibodies for preventing mucosal acquisition and transmission of SARS-CoV-2.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Rodent models for oral microbiome research: considerations and challenges- a mini review.Frontiers in oral health · 2024Review
- Association between periodontal disease and chronic obstructive pulmonary disease.The Japanese dental science review · 2023Review
- Oral pathogens exacerbate Parkinson's disease by promoting Th1 cell infiltration in mice.Microbiome · 2023Article
- [Oral Microbiome and Systemic Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Review
- Innovative biomaterials for the treatment of periodontal disease.Frontiers in dental medicine · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence suggests that periodontitis, characterized by oral dysbiosis, is a critical player in the progression of multiple systemic diseases in humans. However, there is still a lack of a proper mouse model of periodontitis with the colonization of human periodontitis-associated bacteria. We here established a new mouse periodontitis model by combining ligation of the second molars with application of subgingival plaques from periodontitis patients. Using 16S rRNA gene sequencing and Taxonomic classification, we found that human periodontitis-associated bacteria efficiently colonized in the mouse model and were enriched in both ligature silk and mouse saliva. Furthermore, the well-recognized periodontal pathogens including
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.