ArticleAmerican journal of translational research2022
Pars plana vitrectomy assisted by intravitreal injection of conbercept enhances the therapeutic effect and quality of life in patients with severe proliferative diabetic retinopathy.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 citations in OpenAlex.
- Clinical efficacy of Conbercept combined with pars plana vitrectomy for proliferative diabetic retinopathy.American journal of translational research · 2026Article
- Comparison of the adjuvant effect of conbercept intravitreal injection at different times before vitrectomy for proliferative diabetic retinopathy.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the application value of intravitreal injection of Conbercept (IVC)-assisted pars plana vitrectomy (PPV) in patients with severe proliferative diabetic retinopathy (PDR).
methodsForty-eight patients with severe PDR who underwent surgical treatment in Chongqing Aier Eye Hospital between October 2019 and June 2021 were retrospectively enrolled, and their clinical data were analyzed. Of them, 22 patients receiving PPV alone were assigned to the PPV group, and the remaining 26 patients treated with IVC-assisted PPV were included in the PPV+IVC group. The intra-operative indicators, postoperative complication rate, visual acuity (VA) improvement, and postoperative quality of life (QoL) were compared between the two groups. The levels of vascular endothelial growth factor (VEGF), placental growth factor (PIGF), and basic fibroblast growth factor (bFGF) in aqueous humor (AH) as well as serum contents of interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were determined by Enzyme Linked Immunosorbent Assay (ELISA).
resultsCompared to the PPV group, the operation time of the PPV+IVC group was significantly shorter, and the incidence of severe intraoperative blood loss (IBL), bipolar electrocoagulation hemostasis, iatrogenic retinal breaks (IRBs), postoperative silicone oil tamponade (SOT), and overall complications were significantly reduced. After surgery, the central macular thickness (CMT) was lower and the best corrected visual acuity (BCVA) assessed by the standard visual acuity chart and VA were significantly more improved in the PPV+IVC group versus the PPV group. After the use of Conbercept, the AH levels of VEGF, PIGF, and bFGF in the PPV+IVC group decreased and were significantly lower than those in the PPV group. The PPV+IVC group also showed lower serum levels of TNF-α, IL-6, and IL-1β than the PPV group.
conclusionsIVC-assisted PPV can effectively reduce the difficulty of surgical treatment for PDR, better improve the postoperative VA of patients, and reduce inflammation with fewer complications.
Indexed as
Identifiers
35273734PMC8902581W4226435668What OpenQuestion holds
Registered trials
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