Evidence map›Paper›PMID 35273725›Full record

ArticleAmerican journal of translational research2022

Di(2-ethylhexyl)phthalate impairs erythropoiesis via inducing Klotho expression and not via bioenergetic reprogramming.

Chang-Yi Tsai, Te-Ping Fang, Shuoh-Wen Chen, Hsiao-Wen Chen, Eric Chang-Yi Lin, Ting-An Lin, Der-Cherng Tarng, Yuan-I Chang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Chang-Yi TsaiDepartment and Institute of Physiology, National Yang Ming Chiao Tung University Taipei 112304, Taiwan.
Te-Ping FangDepartment and Institute of Physiology, National Yang Ming Chiao Tung University Taipei 112304, Taiwan.
Shuoh-Wen ChenDepartment and Institute of Physiology, National Yang Ming Chiao Tung University Taipei 112304, Taiwan.
Hsiao-Wen ChenDepartment and Institute of Physiology, National Yang Ming Chiao Tung University Taipei 112304, Taiwan.
Eric Chang-Yi LinDepartment and Institute of Physiology, National Yang Ming Chiao Tung University Taipei 112304, Taiwan.
Ting-An LinDepartment and Institute of Physiology, National Yang Ming Chiao Tung University Taipei 112304, Taiwan.
Der-Cherng TarngDepartment and Institute of Physiology, National Yang Ming Chiao Tung University Taipei 112304, Taiwan.
Yuan-I ChangDepartment and Institute of Physiology, National Yang Ming Chiao Tung University Taipei 112304, Taiwan.
National Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Di(2-ethylhexyl)phthalate (DEHP) is the most widely used phthalate to manufacture various plastic products. However, the potential effects of DEHP on erythropoiesis have not been investigated comprehensively. Here, we aimed to investigate whether DEHP modulated the function of hematopoietic stem and progenitor cells (HSPCs) to influence erythropoiesis, and to explore the associated mechanisms. In the present study, human cell lines with a capacity to differentiate into erythroid cells and murine bone marrow cells were treated with DEHP. DEHP not only impaired HSPC function, but also suppressed erythroid differentiation in a dose-dependent manner. In addition, DEHP removal restored HSPC activity. To explore how DEHP interfered with erythroid differentiation, we focused on energy metabolism and Klotho expression. DEHP suppressed erythroid differentiation via upregulating Klotho expression, while it did not via modulating cellular bioenergetics. Therefore, our results provided a novel insight into the pathophysiological link between phthalates and dysregulated erythroid differentiation.

Indexed as

bioenergeticsDEHPerythroid differentiationKlothophthalates

Identifiers

PMID35273725
PMCPMC8902563
OpenAlexW4226200986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.