ReviewAmerican journal of translational research2022
Cross-linking methods of type I collagen-based scaffolds for cartilage tissue engineering.
Review in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Design and applications of barrier membranes for guided bone regeneration.Bioactive materials · 2026Review
- High-Density, Extrudable Collagen Types I and II Microfiber-Based Inks for Tissue Engineering Applications.Polymers · 2026Article
- Methacrylation of Fibrillar Sea Urchin Collagen: Production of Sustainable, Stable, and Functional Hydrogels.ACS omega · 2026Article
- Comparison of Crosslinking Reagents and Their Impacts on Bone Derived ECM Hydrogels.Advanced healthcare materials · 2026Article
- Developing a Clinically Practical Biomaterial Platform for Endogenous Liver Regeneration.Gels (Basel, Switzerland) · 2026Review
- Comparative evaluation of 3D culture strategies for pulp-dentin models.BMC oral health · 2026Article
- Versatility of Collagen as a Natural Biopolymer for Biomedical, Food, and Cosmetic Applications.Current protein & peptide science · 2026Review
- Hydrogel Based on Decellularized Bovine Trabecular Extracellular Matrix Enriched with Type I Collagen.ACS omega · 2025Article
- Dialdehyde Starch Cross-Linked Collagen with Heparin Conjugation: Characterization and Feasibility Study for Osteochondral Tissue Repair.Gels (Basel, Switzerland) · 2025Article
- Chemical Crosslinking of Acid Soluble Collagen Fibres.Biomimetics (Basel, Switzerland) · 2025Review
- Efficacy of Cross-Linked Collagen Membranes for Bone Regeneration: In Vitro and Clinical Studies.Bioengineering (Basel, Switzerland) · 2025Article
- Reinforcement of Fibrillar Collagen Hydrogels with Bioorthogonal Covalent Crosslinks.Biomacromolecules · 2025Article
- Recent Advancements in Marine Collagen: Exploring New Sources, Processing Approaches, and Nutritional Applications.Marine drugs · 2025Review
- Interpenetrating networks of fibrillar and amorphous collagen promote cell spreading and hydrogel stability.Acta biomaterialia · 2025Article
- Wood-Derived Hydrogels for Osteochondral Defect Repair.ACS nano · 2025Article
- Collagen-Based Scaffolds for Meniscal Repair and Regeneration.Journal of tissue engineering and regenerative medicine · 2025Review
- Investigating the impact of microcalcification size and volume on collagenous matrix and tissue mechanics using a tissue-engineered atherosclerotic cap model.Frontiers in cardiovascular medicine · 2025Article
- Embedded 3D Bioprinting of Collagen Inks into Microgel Baths to Control Hydrogel Microstructure and Cell Spreading.Advanced healthcare materials · 2024Article
- Engineered nanofibrillar collagen with tunable biophysical properties for myogenic, endothelial, and osteogenic cell guidance.Acta biomaterialia · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cartilage defects are one of the hardest injures to cure, given the limited regenerative ability of cartilage tissues. Moreover, cartilage defects affect an increasing number of people worldwide. Therefore, scientists have attempted to develop effective strategies to repair cartilage defects in recent years. Recent advances in tissue engineering have led to the strategies for inducing cartilage regeneration. Among the emerging strategies, scaffolds are commonly used in cartilage tissue engineering (CTE) as they provide favorable environment for the growth and proliferation of chondrocytes. An ideal scaffolding material should be highly biocompatible. Type I collagen is one such material, which is widely used in CTE. However, type I collagen has poor mechanical properties and stability, which limit its use. Cross-linking is a simple method known to improve degradability, biological and mechanical properties of biomaterials by enhancing chemical and physical interactions between polymers. Cross-linking can be induced through chemical, physical or biological processes. In this review, we present cross-linking methods that can enhance the mechanical strength of type I collagen for CTE and highlight future directions in this field.
Indexed as
Identifiers
35273719PMC8902548What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.