ReviewAmerican journal of translational research2022
Rethinking autism: the impact of maternal risk factors on autism development.
Review in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- The Biochemical Effects of Resveratrol Intake on the Neurobehavioral Aspects of Autism Spectrum Disorders: A Systematic Review.Central nervous system agents in medicinal chemistry · 2026Pooled it
- Association between type 1 diabetes and neurodevelopmental disorders in children and adolescents: A systematic review and meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Maternal and neonatal cytokine profiles in a twin cohort: evidence from an exploratory pilot study of perinatal immune dysregulation in autism.Pediatric research · 2026Article
- Maternal Prenatal Supplements Intake and Dietary Sources and Their Relation to Autism Spectrum Disorder in the Population of Bangladesh.Public health challenges · 2026Article
- Maternal Thyroid Hormone Imbalance and Risk of Autism Spectrum Disorder.The Journal of clinical endocrinology and metabolism · 2026Article
- Advancing understanding of the mechanisms of autism spectrum disorder through perinatal risk factors.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Prenatal and birth factors associated with child autism diagnosis: a birth cohort perspective.Pediatric research · 2026Article
- Comparison of autism domains across thirty rare variant genotypes.EBioMedicine · 2025Article
- Relationship Between Autism Spectrum Disorder and Maternal Exposure to Passive Smoking and Environmental Factors: A Case-Control Study in Bangladesh.Health science reports · 2025Article
- Prenatal exposure to hypoxic risk conditions in autistic and neurotypical youth: Associated ventricular differences, sleep disturbance, and sensory processing.Autism research : official journal of the International Society for Autism Research · 2024Article
- Exposure to Environmental Pesticides and the Risk of Autism Spectrum Disorders: A Population-Based Case-Control Study.Medicina (Kaunas, Lithuania) · 2024Article
- Risk cycling in diabetes and autism spectrum disorder: a bidirectional Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Unveiling the influences of prenatal and maternal factors on the journey of an autistic child.Frontiers in psychiatry · 2024Article
- Metabolomics: Perspectives on Clinical Employment in Autism Spectrum Disorder.International journal of molecular sciences · 2023Review
- Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Potential Diagnostic Biomarkers in Autism Spectrum Disorders: A Preliminary Study.International journal of molecular sciences · 2023Article
- Enhanced Expression of Human Endogenous Retroviruses, TRIM28 and SETDB1 in Autism Spectrum Disorder.International journal of molecular sciences · 2022Article
- Brain-derived neurotrophic factor levels and oxidative stress in autism: evidence from children and a mouse model.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorders (ASD) are a group of lifelong neurodevelopmental disorders characterized by cognitive deficits and impaired social and communicative development that have been rising in prevalence in recent decades. These disorders may be accompanied by disabling health issues and often lead to a substantial economic burden. The causes and mechanisms of ASD have not yet been fully elucidated, although it has been reported that genetic background, epigenetic modification, and environmental risk factors all contribute to the development of ASD. Environmental factors, which include prenatal circumstances or events, all play a very important role in the early development of autism, yet the exact mechanism remains largely undetermined. In this review, we promote a 'rethinking' of autism as a neurodevelopmental disease that originates from early life development. We focus on the impact of the prenatal and maternal risk factors such as maternal diabetes, prenatal chemical exposure, and hormone imbalances during pregnancy on the risk for ASD development in children and offspring, identifying important pathological bases and prevention measures for future decades. Further research focused on understanding the role of the environmental factors in the etiology of ASD will drive forward innovation strategies towards intervention and the prevention of the maternal risk factors for autism.
Indexed as
Identifiers
35273718PMC8902545W4226166140What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.