ArticleAmerican journal of translational research2022
Clinical characteristics and prognosis of patients with Castleman disease in a Chinese hospital: paraneoplastic pemphigus is an independent risk factor.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Exploring castleman disease in a cohort of hispanic patients: a recognition to its histopathology.Journal of hematopathology · 2025Article
- Castleman disease coexisting with papillary thyroid carcinoma: A case report.Oncology letters · 2025Article
- Paraneoplastic pemphigus: Diagnostic mimics, confounders and management challenges in a series of five long-term survivors from a single centre.Skin health and disease · 2023Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
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Abstract
objectiveCastleman disease (CD) is a rare lymphoproliferative disorder with limited clinical research data. This study aimed to investigate the clinical manifestations, pathologic features, and prognostic factors of CD.
methodsThe clinicopathological data of 54 patients with CD hospitalized in the First Affiliated Hospital of Nanjing Medical University were retrospectively analyzed. Univariate analysis and multivariate analysis were performed by Cox regression model to determine independent prognostic factors for patients' survival.
resultsAccording to clinical classification, 30 cases (55.6%) had unicentric CD (UCD) and 24 cases (44.4%) had multicentric CD (MCD). Moreover, pathologic classification revealed 32 cases (59.3%) with hyaline vascular variant, 3 (5.6%) with mixed cellular variant, and 19 (35.2%) with plasmacytic variant. Patients with MCD commonly presented with clinical signs and symptoms, including fever, splenomegaly, and pleural effusion and/or ascites. Clinical complications, such as liver injury, anemia, and polyradiculoneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes (POEMS) syndrome were more common in patients with MCD. Univariate analysis showed that the presence of paraneoplastic pemphigus (PNP) and the elevation of C-reactive protein were unfavorable prognosticators of survival in patients with CD. By multivariate analysis PNP was an independent prognostic factor in patients with CD.
conclusionsThis study provided a panoramic elaboration of CD cases and showed that the presence of PNP was an independent unfavorable factor.
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35273707PMC8902542W4226506518What OpenQuestion holds
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