The up-regulation of LRIG1 expression inhibits the proliferation, apoptosis and invasion of glioma cells.

Zhiyong Zhang, Yuanyuan Wang, Xianxing Wang, Hongguang Zhang, Shuai Wang

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In one paragraph

Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 63% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Preservation of 5-Hydroxymethylcytosine Levels inGenes · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Zhiyong ZhangDepartment of Neurosurgery, Caoxian People's Hospital Heze 274400, Shandong, China.

Yuanyuan WangDepartment of Oncology, Linyi People's Hospital Linyi 251500, Shandong, China.

Xianxing WangDepartment of Neurosurgery, Yuncheng County People's Hospital Heze 274700, Shandong, China.

Hongguang ZhangDepartment of Neurosurgery, Gaotang People's Hospital Liaocheng 252800, Shandong, China.

Shuai WangDepartment of Neurosurgery, First Hospital of Zibo Zibo 255200, Shandong, China.

Central Hospital of Zibo · CNCixian People's Hospital · CNLiaocheng People's Hospital · CNLinyi People's Hospital · CNZoucheng People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo illustrate the role of LRIG1 in regulating the Notch signaling pathway and glioma cell proliferation, apoptosis and invasion.

methodsThe glioma cells (U373) were divided into control group, NC group and LRIG1 group. After transfection, the CCK-8 assay, Transwell assay, and Flow cytometry were used to explore the biological function of LRIG1 in glioma cells. At the end, Western blot was used to detect the expression of LRIG1, Notch1, Hes1, Bcl-2, and Bax.

resultsThe LRIG1 expression in U373 cells was remarkably lower than that in normal glial cells (

conclusionThe up-regulation of LRIG1 can inhibit the proliferation and migration of glioma cells and promote apoptosis by regulating the Notch signaling pathway.

Indexed as

apoptosiscell invasioncell proliferationgliomaLRIG1notch signal

Identifiers

PMID35273685

PMCPMC8902577

OpenAlexW4226198776

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.