Evidence map›Paper›PMID 35273682›Full record

ArticleAmerican journal of translational research2022

A novel signal enhancement strategy for the detection of DNA oxidative damage biomarker 8-OHdG based on the synergy between β-CD-CuNCs and multi-walled carbon nanotubes.

Ruoting Lin, Shuang Zhou, Huanan Zhao, Huasong Lin, Lixing Wang, Weipeng Hu, Hongzhi Gao, Bin Qiu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ruoting LinDepartment of Neurology, Second Affiliated Hospital of Fujian Medical University Quanzhou 362000, Fujian, China.
Shuang ZhouClinical Center of Molecular Diagnosis and Therapy, Second Affiliated Hospital of Fujian Medical University Quanzhou 362000, Fujian, China.
Huanan ZhaoMinistry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University Fuzhou 350108, Fujian, China.
Huasong LinDepartment of Neurology, Second Affiliated Hospital of Fujian Medical University Quanzhou 362000, Fujian, China.
Lixing WangClinical Center of Molecular Diagnosis and Therapy, Second Affiliated Hospital of Fujian Medical University Quanzhou 362000, Fujian, China.
Weipeng HuDepartment of Neurosurgery, Second Affiliated Hospital of Fujian Medical University Quanzhou 362000, Fujian, China.
Hongzhi GaoClinical Center of Molecular Diagnosis and Therapy, Second Affiliated Hospital of Fujian Medical University Quanzhou 362000, Fujian, China.
Bin QiuMinistry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University Fuzhou 350108, Fujian, China.
Fujian Medical University · CNFuzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo propose a novel signal enhancement strategy based on the synergy between β-CD-CuNCs and multi-walled carbon nanotubes (MWCNTs) for the detection of DNA oxidative damage biomarker 8-Hydroxy-2'-deoxyguanosine (8-OHdG).

methodsThe sensor was constructed with the β-CD-CuNCs-MWCNTs-nafion film and successfully used for the quantitative detection of 8-OhdG in the presence of biomolecules such as ascorbic acid (AA) and uric acid (UA). To investigate the surface morphology of the modified electrode, Transmission Electron Microscopy (TEM), Cyclic Voltammetry (CV) and Electrochemical Impedance Spectroscopy (EIS) were performed on bare and modified electrodes.

resultsAccording to Differential Pulse Voltammetry (DPV) results, there was a linear relationship between peak current and concentration of 8-OhdG, ranging from 1.0×10

conclusionsThe proposed sensor had been successfully applied to the determination of 8-OHdG in human urine samples with high recovery rates.

Indexed as

8-Hydroxy-2’-deoxyguanosineCarboxyl-multi-walled carbon nanotubesDNA oxidative damageelectrochemical biosensorβ-CD-CuNCs

Identifiers

PMID35273682
PMCPMC8902525
OpenAlexW4226350934

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.