Evidence map›Paper›PMID 35273650›Full record

ArticleMind, brain and education : the official journal of the International Mind, Brain, and Education Society2022

Mechanisms by which Early Eye Gaze to the Mouth During Multisensory Speech Influences Expressive Communication Development in Infant Siblings of Children with and without Autism.

Pooja Santapuram, Jacob I Feldman, Sarah M Bowman, Sweeya Raj, Evan Suzman, Shannon Crowley, So Yoon Kim, Bahar Keceli-Kaysili, Kristen Bottema-Beutel, David J Lewkowicz and 2 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Mind, brain and education : the official journal of the International Mind, Brain, and Education Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06794476 (Milieu Teaching-AV), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06794476 nawithdrawnnot on this mapstarted 2026, after this paper: background citation

Milieu Teaching-AV (MT-AV Pilot): A Pilot Study to Assess the Feasibility of an Adaptation of Milieu Teaching for Infant Siblings of Autistic Children That Encourages Looking to the Mouth

TypeinterventionalSponsorFather Flanagan's Boys' HomeRan2026 to 2026Enrolled0ConditionsAutism Sibling, Autism Spectrum DisorderArmsMilieu Teaching-AV
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Relations Between Preferential Looking to Synchronous Audiovisual Speech and Expressive Language in Infants With Autistic and Non-Autistic Siblings.Mind, brain and education : the official journal of the International Mind, Brain, and Education Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Pooja SantapuramVanderbilt School of Medicine, Vanderbilt University, Nashville, TN, USA.
Jacob I FeldmanDepartment of Hearing & Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Sarah M BowmanDepartment of Hearing & Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Sweeya RajNeuroscience Undergraduate Program, Vanderbilt University, Nashville, TN, USA.
Evan SuzmanMaster's Program in Biomedical Sciences, Vanderbilt University, Nashville, TN, USA.
Shannon CrowleyLynch School of Education and Human Development, Boston College, Boston, MA, USA.
So Yoon KimPresent Affiliation: Department of Teacher Education, Duksung Women's University, Seoul, South Korea.
Bahar Keceli-KaysiliDepartment of Hearing & Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Kristen Bottema-BeutelLynch School of Education and Human Development, Boston College, Boston, MA, USA.
David J LewkowiczHaskins Laboratories, Yale Child Study Center, New Haven, CT, USA.
Mark T WallaceDepartment of Hearing & Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Tiffany G WoynaroskiDepartment of Hearing & Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt University · USAllen Institute for Brain Science · USBoston College · USVanderbilt University Medical Center · USDuksung Women's University · KRHaskins Laboratories · USUniversity of Georgia · US

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
NRSA Training CoreTL1TR002244 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$4.6M
Sensory Project in Infant/Toddler Siblings of Children with Autism (Project SPIS)R01DC020186 · NIDCD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Tiffany Woynaroski · 2022 to 2026
$3.2M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)KL2TR000446 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$2.8M
Sensory Project in Infant/Toddler Siblings of Children with Autism (Project SPIS)R21DC016144 · NIDCD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WOYNAROSKI, TIFFANY · 2017 to 2019
$474k
NCATS NIH HHS KL2 TR000446NCATS NIH HHS TL1 TR002244NICHD NIH HHS P50 HD103537NICHD NIH HHS U54 HD083211NIDCD NIH HHS R01 DC020186NIDCD NIH HHS R21 DC016144
6 · The paper itself

Abstract

Looking to the mouth of a talker early in life predicts expressive communication. We hypothesized that looking at a talker's mouth may signal that infants are ready for increased supported joint engagement and that it subsequently facilitates prelinguistic vocal development and translates to broader gains in expressive communication. We tested this hypothesis in 50 infants aged 6-18 months with heightened and general population-level likelihood of autism diagnosis (Sibs-autism and Sibs-NA; respectively). We measured infants' gaze to a speaker's face using an eye tracking task, supported joint engagement during parent-child free play sessions, vocal complexity during a communication sample, and broader expressive communication. Looking at the mouth was indirectly associated with expressive communication via increased higher-order supported joint engagement and vocal complexity. This indirect effect did not vary according to sibling status. This study provides preliminary insights into the mechanisms by which looking at the mouth may influence expressive communication development.

Indexed as

autismbaby sibseye gazelanguagemediationselective attentionvocalizations

Identifiers

PMID35273650
PMCPMC8903197
OpenAlexW4205894316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.