Evidence map›Paper›PMID 35273616›Full record

ArticleFrontiers in immunology2022

Rotenone Modulates

Danielle F Mello, Christina M Bergemann, Kinsey Fisher, Rojin Chitrakar, Shefali R Bijwadia, Yang Wang, Alexis Caldwell, Larry Ryan Baugh, Joel N Meyer

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Progeny effects of rotenone exposure depend on parental toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
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  14. Review
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  16. Rotenone ModulatesFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Danielle F MelloNicholas School of the Environment, Duke University, Durham, NC, United States.
Christina M BergemannNicholas School of the Environment, Duke University, Durham, NC, United States.
Kinsey FisherDepartment of Biology, Duke University, Durham, NC, United States.
Rojin ChitrakarDepartment of Biology, Duke University, Durham, NC, United States.
Shefali R BijwadiaNicholas School of the Environment, Duke University, Durham, NC, United States.
Yang WangNicholas School of the Environment, Duke University, Durham, NC, United States.
Alexis CaldwellNicholas School of the Environment, Duke University, Durham, NC, United States.
Larry Ryan BaughDepartment of Biology, Duke University, Durham, NC, United States.
Joel N MeyerNicholas School of the Environment, Duke University, Durham, NC, United States.
Duke University · US

Funding

Zebrafish as a Detector of Organophosphate ExposureP42ES010356 · NIEHS · DUKE UNIVERSITY · PI AMY H HERRING · 2000 to 2026
$56.2M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Duke University Program in Environmental HealthT32ES021432 · NIEHS · DUKE UNIVERSITY · PI Akhenaton-Andrew Dhafir Jones, Joel Newman Meyer · 2013 to 2026
$4.0M
Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes?R01ES028218 · NIEHS · DUKE UNIVERSITY · PI MEYER, JOEL NEWMAN · 2017 to 2021
$1.5M
NIEHS NIH HHS P42 ES010356NIEHS NIH HHS R01 ES028218NIEHS NIH HHS T32 ES021432NIH HHS P40 OD010440
6 · The paper itself

Abstract

Mitochondria are central players in host immunometabolism as they function not only as metabolic hubs but also as signaling platforms regulating innate immunity. Environmental exposures to mitochondrial toxicants occur widely and are increasingly frequent. Exposures to these mitotoxicants may pose a serious threat to organismal health and the onset of diseases by disrupting immunometabolic pathways. In this study, we investigated whether the Complex I inhibitor rotenone could alter

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsDimethyl SulfoxideEscherichia coliPseudomonas aeruginosaRotenoneCaenorhabditis elegans ProteinsDimethyl SulfoxideRotenoneimmunotoxicityinnate immunityinvertebratemetabolismmitochondrial toxicantsmitoimmunitypesticides

Identifiers

PMID35273616
PMCPMC8902048
OpenAlexW4213258126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.