ArticleFrontiers in aging neuroscience2022
Enhanced Interplay of Neuronal Coherence and Coupling in the Dying Human Brain.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07477028 (Feasibility of Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence), which is not on this map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility of Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence: A Prospective Observational Study (NeuroCogPresv)
Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- Near-Death Experiences in Adult ICU Patients: A Scoping Review.Nursing in critical care · 2026Article
- Neural regions associated with memories of Recalled Experiences of Death (REDs; authentic Near‑Death Experiences [NDEs]): a preliminary functional MRI study.Resuscitation plus · 2026Article
- Self-reported near-death and near-death-like experiences in a Chinese online sample: an exploratory mixed-methods study.Frontiers in psychology · 2026Article
- γ neuromodulations: unraveling biomarkers for neurological and psychiatric disorders.Military Medical Research · 2025Review
- Life in Suspension with Death: Biocultural Ontologies, Perceptual Cues, and Biomarkers for the Tibetan Tukdam Postmortem Meditative State.Culture, medicine and psychiatry · 2025Article
- A neuroscientific model of near-death experiences.Nature reviews. Neurology · 2025Review
- Consciousness in deep hypothermic circulatory arrest: a feasibility study.Journal of cardiothoracic surgery · 2025Article
- Local field potential changes during euthanasia may parallel with near death experience.Scientific reports · 2025Article
- Threats and Mitigation Strategies for Electroencephalography-Based Person Authentication.International journal of telemedicine and applications · 2025Review
- An encounter with death: a comparative thematic and content analysis of naturalistic DMT experiences and the near-death experience.Frontiers in psychology · 2025Article
- The central clinical relevance of near-death experiences in acute care contexts: identification, prediction, and management.Frontiers in psychology · 2025Article
- Consciousness and the Dying Brain.Anesthesiology · 2024Review
- Variation and convergence in the morpho-functional properties of the mammalian neocortex.Frontiers in systems neuroscience · 2024Review
- Reduced Heartbeat-Evoked Responses in a Near-Death Case Report.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Do not go gently into that good night: The dying brain and its paradoxically heightened electrical activity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Surge of neurophysiological coupling and connectivity of gamma oscillations in the dying human brain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Induced Coma, Death, and Organ Transplantation: A Physiologic, Genetic, and Theological Perspective.International journal of molecular sciences · 2023Review
- Lapses of the Heart: Frequency and Subjective Salience of Impressions Reported by Patients after Cardiac Arrest.Journal of clinical medicine · 2023Article
- Between life and death: the brain twilight zones.Frontiers in neuroscience · 2023Review
- What happens in the brain when we die? Deciphering the neurophysiology of the final moments in life.Frontiers in aging neuroscience · 2023Review
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Authors and funding
13 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neurophysiological footprint of brain activity after cardiac arrest and during near-death experience (NDE) is not well understood. Although a hypoactive state of brain activity has been assumed, experimental animal studies have shown increased activity after cardiac arrest, particularly in the gamma-band, resulting from hypercapnia prior to and cessation of cerebral blood flow after cardiac arrest. No study has yet investigated this matter in humans. Here, we present continuous electroencephalography (EEG) recording from a dying human brain, obtained from an 87-year-old patient undergoing cardiac arrest after traumatic subdural hematoma. An increase of absolute power in gamma activity in the narrow and broad bands and a decrease in theta power is seen after suppression of bilateral hemispheric responses. After cardiac arrest, delta, beta, alpha and gamma power were decreased but a higher percentage of relative gamma power was observed when compared to the interictal interval. Cross-frequency coupling revealed modulation of left-hemispheric gamma activity by alpha and theta rhythms across all windows, even after cessation of cerebral blood flow. The strongest coupling is observed for narrow- and broad-band gamma activity by the alpha waves during left-sided suppression and after cardiac arrest. Albeit the influence of neuronal injury and swelling, our data provide the first evidence from the dying human brain in a non-experimental, real-life acute care clinical setting and advocate that the human brain may possess the capability to generate coordinated activity during the near-death period.
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