ReviewNature medicine2022
An epidemic of uncertainty: rumors, conspiracy theories and vaccine hesitancy.
Review in Nature medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
147 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Social media-based interventions for improving vaccine uptake, reducing hesitancy, and combating misinformation: a comprehensive systematic review and meta-analysis of RCT.BMC public health · 2026Pooled it
- Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990-2021: a systematic analysis from the Global Burden of Disease Study 2021.The Lancet. Infectious diseases · 2024Pooled it
- Video and Infographic Messages From Primary Care Physicians and Influenza Vaccination Rates: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Tough talks COVID-19 (TT-C) digital health intervention: multistate randomized controlled trial.Scientific reports · 2025Trial
- The syndemic nexus: How vaccine hesitancy and COVID-19 interact to influence vaccine uptake among university students.Human vaccines & immunotherapeutics · 2026Article
- Shared clinical decision-making for vaccination: A view through the lens of mid-adult HPV vaccination.Human vaccines & immunotherapeutics · 2026Article
- Understanding the practices and perceptions of Chinese older adults towards vaccination in the context of COVID-19: A qualitative study in Anhui Province.Human vaccines & immunotherapeutics · 2026Article
- Bakteriopolis: Introducing Microbes to Society.Microbial biotechnology · 2026Review
- Making US public health a good idea again.Lancet regional health. Americas · 2026Review
- Evaluating COVID-19 vaccine allocation policies using Bayesian m-top exploration.Scientific reports · 2026Article
- Effect of a pharmacist-led infodemic management intervention on perception, willingness to receive and pay for adult vaccines among civil servants in Akwa Ibom State, Nigeria.BMC infectious diseases · 2026Article
- Hesitancy towards the COVID-19 booster vaccination: a thematic analysis from a focus group study in Spain.BMC public health · 2026Article
- Evaluating the efficacy of digital media platforms in disseminating public health information: A global review with implications for South Africa.African journal of primary health care & family medicine · 2026Review
- Article
- A cross-sectional survey of false beliefs about COVID-19 and their association with vaccine hesitancy and uptake in the United States and China.PLOS global public health · 2026Article
- Article
- Understanding COVID-19 vaccine hesitancy among older adults in post-zero-COVID China: a predictive modeling study.BMC geriatrics · 2025Article
- Factors influencing healthcare workers' vaccine recommendations: A cross-sectional study in Zhejiang Province, China.Human vaccines & immunotherapeutics · 2025Article
- Mapping Eight Decades of Vaccination Social Science: Bibliometric Analysis of Global Research Trends.Vaccines · 2025Review
- Vaccine confidence and potential implications for new tuberculosis vaccines.BMC global and public health · 2025Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 'infodemic' continues to undermine trust in vaccination efforts aiming to bring an end to the pandemic. However, the challenge of vaccine hesitancy is not only a problem of the information ecosystem and it often has little to do with the vaccines themselves. In this Perspective, we argue that the epidemiological and social crises brought about by COVID-19 have magnified widely held social anxieties and trust issues that, in the unique circumstances of this global pandemic, have exacerbated skepticism toward vaccines. We argue that trust is key to overcoming vaccine hesitancy, especially in a context of widespread social uncertainty brought about by the pandemic, where public sentiment can be volatile. Finally, we draw out some implications of our argument for strategies to build vaccine confidence.
Indexed as
Identifiers
35273403What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.