Evidence map›Paper›PMID 35273317›Full record

ArticleScientific reports2022

A proposal for the reference intervals of the Italian microbiota "scaffold" in healthy adults.

Davide Sisti, Valerio Pazienza, Fabio Piccini, Barbara Citterio, Wally Baffone, Sabrina Donati Zeppa, Francesca Biavasco, Emilia Prospero, Antonio De Luca, Marco Artico and 10 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Defining reference values for the gut microbiota in a Southern European population.Frontiers in cellular and infection microbiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 1 country.

Davide Sisti *Department of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza Rinascimento 7, 61029, Urbino, Italy.
Valerio Pazienza *Division of Gastroenterology, IRCCS "Casa Sollievo della Sofferenza" Hospital, 71013, San Giovanni Rotondo, Italy.
Fabio Piccini *Italian Microbiome Project, 35100, Padua, Italy.
Barbara CitterioDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza Rinascimento 7, 61029, Urbino, Italy.
Wally BaffoneDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza Rinascimento 7, 61029, Urbino, Italy.
Sabrina Donati ZeppaDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza Rinascimento 7, 61029, Urbino, Italy.
Francesca BiavascoDepartment of Life and Environmental Sciences, Università Politecnica delle Marche, 60121, Ancona, Italy.
Emilia ProsperoDepartment of Biomedical Sciences, Università Politecnica delle Marche, 60121, Ancona, Italy.
Antonio De LucaDepartment of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy.
Marco ArticoDepartment of Sense Organs, La Sapienza University, 00185, Rome, Italy.
Samanta TauroneDepartment of Sense Organs, La Sapienza University, 00185, Rome, Italy.
Andrea MinelliDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza Rinascimento 7, 61029, Urbino, Italy.
Francesco PerriDivision of Gastroenterology, IRCCS "Casa Sollievo della Sofferenza" Hospital, 71013, San Giovanni Rotondo, Italy.
Elena BindaCancer Stem Cells Unit ISBReMIT, IRCCS "Casa Sollievo della Sofferenza" Hospital, 71013, San Giovanni Rotondo, Italy.
Riccardo PracellaCancer Stem Cells Unit ISBReMIT, IRCCS "Casa Sollievo della Sofferenza" Hospital, 71013, San Giovanni Rotondo, Italy.
Riccardo SantoliniDepartment of Humanities, University of Urbino Carlo Bo, 61029, Urbino, Italy.
Stefano AmatoriDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza Rinascimento 7, 61029, Urbino, Italy. stefano.amatori1@uniurb.it.
Piero SestiliDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza Rinascimento 7, 61029, Urbino, Italy.
Marco B L RocchiDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza Rinascimento 7, 61029, Urbino, Italy.
Pietro GobbiDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza Rinascimento 7, 61029, Urbino, Italy.
University of Urbino · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITMarche Polytechnic University · ITSapienza University of Rome · ITCasa Sollievo della Sofferenza · ITTechnobiochip (Italy) · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous factors, ranging from genetics, age, lifestyle, and dietary habits to local environments, contribute to the heterogeneity of the microbiota in humans. Understanding the variability of a "healthy microbiota" is a major challenge in scientific research. The gut microbiota profiles of 148 healthy Italian volunteers were examined by 16S rRNA gene sequencing to determine the range and diversity of taxonomic compositions in the gut microbiota of healthy populations. Possible driving factors were evaluated through a detailed anamnestic questionnaire. Microbiota reference intervals were also calculated. A "scaffold" of a healthy Italian gut microbiota composition was identified. Differences in relative quantitative ratios of microbiota composition were detected in two clusters: a bigger cluster (C

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAdultFecesFeeding BehaviorHumansRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID35273317
PMCPMC8913673
OpenAlexW4220959309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.