ArticleScientific reports2022
Thermometric lateral flow immunoassay with colored latex beads as reporters for COVID-19 testing.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 27 citations in OpenAlex.
- Development and application of a smartphone-based thermal contrast amplification reader for photothermal lateral flow immunoassays.Microsystems & nanoengineering · 2026Article
- Surfactant-free polymer microspheres with molecular confinement-enabled optical encoding for dual-color immunochromatographic assays.Mikrochimica acta · 2026Article
- Sensitivity Enhancement of Multiplex Lateral Flow Immunoassays by NIR-II Fluorescence and Thermal Contrast.Analytical chemistry · 2026Article
- Triggered "Capture-and-Release" Enables a High-Affinity Rebinding Strategy for Sensitivity Enhancement in Lateral Flow Assays.ACS sensors · 2025Article
- Core-shell ZIF-8@Au labels for high-sensitivity lateral flow assays via thiol-functionalization and seed-mediated growth.Mikrochimica acta · 2025Article
- Aggregation-Induced Emission-Based Lateral Flow Immunoassay for Ultra-Sensitive and On-Site Detection of Porcine Epidemic Diarrhea Virus.Biosensors · 2025Article
- Polymer Colloids: Current Challenges, Emerging Applications, and New Developments.Macromolecules · 2023Review
- Red-Emitting Latex Nanoparticles by Stepwise Entrapment of β-Diketonate Europium Complexes.International journal of molecular sciences · 2022Article
- Nanomaterial and interface advances in immunoassay biosensors.The journal of physical chemistry. C, Nanomaterials and interfaces · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temperature sensing is a promising method of enhancing the detection sensitivity of lateral flow immunoassay (LFIA) for point-of-care testing. A temperature increase of more than 100 °C can be readily achieved by photoexcitation of reporters like gold nanoparticles (GNPs) or colored latex beads (CLBs) on LFIA strips with a laser power below 100 mW. Despite its promise, processes involved in the photothermal detection have not yet been well-characterized. Here, we provide a fundamental understanding of this thermometric assay using non-fluorescent CLBs as the reporters deposited on nitrocellulose membrane. From a measurement for the dependence of temperature rises on the number density of membrane-bound CLBs, we found a 1.3-fold (and 3.2-fold) enhancement of the light absorption by red (and black) latex beads at 520 nm. The enhancement was attributed to the multiple scattering of light in this highly porous medium, a mechanism that could make a significant impact on the sensitivity improvement of LFIA. The limit of detection was measured to be 1 × 10
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