Evidence map›Paper›PMID 35273234›Full record

ArticleScientific reports2022

Anti-SARS-CoV-2 equine F (Ab')

Viviane Fongaro Botosso, Soraia Attie Calil Jorge, Renato Mancini Astray, Ana Marcia de Sá Guimarães, Monica Beatriz Mathor, Patrícia Dos Santos de Carneiro, Edison Luiz Durigon, Dimas Covas, Danielle Bruna Leal de Oliveira, Ricardo das Neves Oliveira and 26 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 2 institutions in 1 country.

Viviane Fongaro Botosso *Virology Laboratory, Butantan Institute, São Paulo, Brazil.
Soraia Attie Calil Jorge *Viral Biotechnology Laboratory, Butantan Institute, São Paulo, Brazil.
Renato Mancini Astray *Multipurpose Laboratory, Butantan Institute, São Paulo, Brazil.
Ana Marcia de Sá Guimarães *Microbiology Department, Biomedical Science Institute, University of São Paulo, São Paulo, Brazil.
Monica Beatriz Mathor *Institute for Energy and Nuclear Research, São Paulo, Brazil.
Patrícia Dos Santos de Carneiro *Quality Control, Butantan Institute, São Paulo, Brazil.
Edison Luiz DurigonMicrobiology Department, Biomedical Science Institute, University of São Paulo, São Paulo, Brazil.
Dimas CovasDirection, Butantan Institute, São Paulo, Brazil.
Danielle Bruna Leal de OliveiraVirology Laboratory, Butantan Institute, São Paulo, Brazil.
Ricardo das Neves OliveiraBioindustrial Center, Butantan Institute, São Paulo, Brazil.
Durvanei Augusto MariaDevelopment and Innovation Laboratory, Butantan Institute, São Paulo, Brazil.
Silas Fernandes EtoDevelopment and Innovation Laboratory, Butantan Institute, São Paulo, Brazil.
Neuza Maria Frazatti GallinaViral Vaccines Pilot Laboratory, Butantan Institute, São Paulo, Brazil.
Giselle PiddeImmunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
Carla Cristina Squaiella-BaptistãoImmunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
Dilza Trevisan SilvaCenter of Excellence in New Target Discovery (CENTD), Special Laboratory, São Paulo, Brazil.
Isadora Maria Villas-BoasImmunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
Dayanne Carla FernandesImmunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
Aline Vivian Vatti AuadaBioindustrial Center, Butantan Institute, São Paulo, Brazil.
Alexandre Campos BanariMicrobiology Department, Biomedical Science Institute, University of São Paulo, São Paulo, Brazil.
Antônio Francisco de Souza FilhoMicrobiology Department, Biomedical Science Institute, University of São Paulo, São Paulo, Brazil.
Camila BianconiBioindustrial Center, Butantan Institute, São Paulo, Brazil.
Carla Lilian de Agostini UtescherVirology Laboratory, Butantan Institute, São Paulo, Brazil.
Denise Cristina André OliveiraVirology Laboratory, Butantan Institute, São Paulo, Brazil.
Douglas Oscar Ceolin MarianoBioindustrial Center, Butantan Institute, São Paulo, Brazil.
Flávia Ferreira BarbosaMultipurpose Laboratory, Butantan Institute, São Paulo, Brazil.
Giuliana RondonDevelopment and Innovation Laboratory, Butantan Institute, São Paulo, Brazil.
Josana KapronezaiVirology Laboratory, Butantan Institute, São Paulo, Brazil.
Juliana Galvão da SilvaQuality Control, Butantan Institute, São Paulo, Brazil.
Mauricio Barbugiani GoldfederDevelopment and Innovation Laboratory, Butantan Institute, São Paulo, Brazil.
Priscila ComoneBioindustrial Center, Butantan Institute, São Paulo, Brazil.
Regis Edgar Castilho JuniorDevelopment and Innovation Laboratory, Butantan Institute, São Paulo, Brazil.
Taiana Tainá Silva PereiraMicrobiology Department, Biomedical Science Institute, University of São Paulo, São Paulo, Brazil.
Fan Hui WenBioindustrial Center, Butantan Institute, São Paulo, Brazil. fan.hui@butantan.gov.br.
Denise V TambourgiImmunochemistry Laboratory, Butantan Institute, São Paulo, Brazil. denise.tambourgi@butantan.gov.br.
Ana Marisa Chudzinski-TavassiDevelopment and Innovation Laboratory, Butantan Institute, São Paulo, Brazil. ana.chudzinski@butantan.gov.br.
Instituto Butantan · BRUniversidade de São Paulo · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo Research Foundation) 2020/05293-0Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development) 301358/2017-6Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development) 303197/2017-0Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development) 305056/2019-0Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development) 401346/2020-0
6 · The paper itself

Abstract

The new outbreak of coronavirus disease 2019 (COVID-19) has infected and caused the death of millions of people worldwide. Intensive efforts are underway around the world to establish effective treatments. Immunoglobulin from immunized animals or plasma from convalescent patients might constitute a specific treatment to guarantee the neutralization of the virus in the early stages of infection, especially in patients with risk factors and a high probability of progressing to severe disease. Worldwide, a few clinical trials using anti-SARS-CoV-2 immunoglobulins from horses immunized with the entire spike protein or fragments of it in the treatment of patients with COVID-19 are underway. Here, we describe the development of an anti-SARS-CoV-2 equine F(ab')

Indexed as

AnimalsCOVID-19Enzyme-Linked Immunosorbent AssayFemaleHorsesHumansImmunoglobulinsMaleMesocricetusPlasmapheresisReceptors, ImmunologicSARS-CoV-2F(ab')2 receptorImmunoglobulinsReceptors, Immunologic

Identifiers

PMID35273234
PMCPMC8913704
OpenAlexW4221085034

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.