Evidence map›Paper›PMID 35273176›Full record

ArticleNature communications2022

Fusobacterium nucleatum reduces METTL3-mediated m

Shujie Chen, Lu Zhang, Mengjie Li, Ying Zhang, Meng Sun, Lingfang Wang, Jiebo Lin, Yun Cui, Qian Chen, Chenqi Jin and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 1 pooled it
19.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 1 synthesis or guideline pooled it, 233 citations in OpenAlex.

  1. Pooled it
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  7. Translational cancer research · 2026
    Article
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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Shujie Chen *Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0001-5099-5569
Lu Zhang *Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Mengjie Li *Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ying Zhang *Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Meng SunDepartment of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Lingfang WangWomen's Hospital, Institute of Genetics, and Department of Environmental Medicine, Zhejiang University School of Medicine, Zhejiang, China.
Jiebo LinWomen's Hospital, Institute of Genetics, and Department of Environmental Medicine, Zhejiang University School of Medicine, Zhejiang, China.
Yun CuiDepartment of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Qian ChenDepartment of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Chenqi JinDepartment of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiang LiDepartment of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Boya WangInstitute of Gastroenterology, Zhejiang University, Hangzhou, China.
Hao ChenSchool of Medicine, Southern University of Science and Technology, Shenzhen, China.
Tianhua ZhouDepartment of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. tzhou@zju.edu.cn.ORCID 0000-0002-1791-2124
Liangjing WangInstitute of Gastroenterology, Zhejiang University, Hangzhou, China. wangljzju@zju.edu.cn.ORCID 0000-0001-8227-8855
Chih-Hung HsuWomen's Hospital, Institute of Genetics, and Department of Environmental Medicine, Zhejiang University School of Medicine, Zhejiang, China. ch_hsu@zju.edu.cn.ORCID 0000-0001-8071-0122
Wei ZhuoDepartment of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. wzhuo@zju.edu.cn.ORCID 0000-0002-8251-4210
Sir Run Run Shaw Hospital · CNWomen's Hospital, School of Medicine, Zhejiang University · CNSouthern University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbiota-host interactions play critical roles in colorectal cancer (CRC) progression, however, the underlying mechanisms remain elusive. Here, we uncover that Fusobacterium nucleatum (F. nucleatum) induces a dramatic decline of m

Indexed as

Colorectal NeoplasmsFusobacterium nucleatumGastrointestinal MicrobiomeMethyltransferasesAnimalsHumansNeoplasm MetastasisSignal TransductionMethyltransferasesMETTL3 protein, human

Identifiers

PMID35273176
PMCPMC8913623
OpenAlexW4220869078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.