Evidence map›Paper›PMID 35273154›Full record

ArticleOncogenesis2022

SIAH1 reverses chemoresistance in epithelial ovarian cancer via ubiquitination of YBX-1.

Wujiang Gao, Lu Chen, Li Lin, Meiling Yang, Taoqiong Li, Hong Wei, Chunli Sha, Jie Xing, Mengxue Zhang, Shijie Zhao and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogenesis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Wujiang Gao *Reproductive Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Lu Chen *Reproductive Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Li LinReproductive Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Meiling YangThe first people's hospital of Nantong, Nantong, China.
Taoqiong LiReproductive Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Hong WeiDepartment of Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Chunli ShaReproductive Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Jie XingReproductive Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Mengxue ZhangReproductive Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Shijie ZhaoReproductive Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Qi ChenDepartment of Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Wenlin XuDepartment of Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Yuefeng LiDepartment of Radiology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Xiaolan ZhuReproductive Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China. zxl2517@163.com.ORCID http://orcid.org/0000-0002-0499-8045
Jiangsu University · CNNantong University · CN

Funding

CAS | Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Science (Institute of Geographic Sciences and Natural Resources Research, CAS) 81672913CAS | Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Science (Institute of Geographic Sciences and Natural Resources Research, CAS) 81871343Excellent Youth Foundation of Jiangsu Scientific Committee FRC201788Excellent Youth Foundation of Jiangsu Scientific Committee QNRC2016460Jiangsu Development and Reform Commission (Jiangsu Development and Reform Commission of China) BE2017698Jiangsu Development and Reform Commission (Jiangsu Development and Reform Commission of China) BE2018693Nantong Municipal Commission of Health and Family Planning QA2020005Natural Science Foundation of Jiangsu Province (Jiangsu Provincial Natural Science Foundation) BK20181226
6 · The paper itself

Abstract

Chemoresistance is a severe outcome among patients with epithelial ovarian cancer (EOC) that leads to a poor prognosis. YBX-1 has been shown to cause treatment failure and cancer progression in EOC. However, strategies that directly target YBX-1 are not yet conceivable. Here, we identified that SIAH1 which was downregulated in chemoresistant EOC samples and cell lines functioned as novel E3 ligases to trigger degradation of YBX-1 at cytoplasm by RING finger domain. Mechanistic studies show that YBX-1 was ubiquitinated by SIAH1 at lys304 that lead to the instability of its target m5C-modified mRNAs, thus sensitized EOC cells to cDDP. Overexpression of SIAH1 enhanced the antitumor efficacy of cisplatin in vitro and in vivo, which were partially impaired by ectopic expression of YBX-1 or depletion of YBX-1 ubiquitination. In summary, our data identify the SIAH1/YBX-1 interaction as a therapeutic target for overcoming EOC chemoresistance.

Identifiers

PMID35273154
PMCPMC8913663
OpenAlexW4221028476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.