Evidence map›Paper›PMID 35273081›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Precise and Pervasive Phasic Bursting in Locus Coeruleus during Maternal Behavior in Mice.

Roman Dvorkin, Stephen D Shea

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Neural circuits for mammalian parental behaviour.Nature reviews. Neuroscience · 2026
    Review
  2. Article
  3. Maternal experience alters brain-wide representation of infant cries.bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Neural plasticity supporting parental behaviors.Current opinion in neurobiology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. The lateral habenula is required for maternal behavior in the mouse dam.bioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Selective deletion ofbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Roman DvorkinCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.ORCID 0000-0003-1586-2394
Stephen D SheaCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 sshea@cshl.edu.ORCID 0000-0001-6927-0189

Funding

Emotional modulation of neural and behavioral responses to social cues by locus coeruleusR01MH119250 · NIMH · COLD SPRING HARBOR LABORATORY · PI SHEA, STEPHEN D · 2019 to 2023
$2.4M
NIMH NIH HHS R01 MH119250
6 · The paper itself

Abstract

The noradrenergic locus coeruleus (LC) mediates key aspects of arousal, memory, and cognition in structured tasks, but its contribution to naturalistic behavior remains unclear. LC activity is thought to multiplex distinct signals by superimposing sustained ("tonic") firing patterns reflecting global brain states, such as arousal and anxiety, and rapidly fluctuating ("phasic") bursts signaling discrete behaviorally significant events. Manipulations of the LC noradrenergic system broadly impair social behavior, but the temporal structure of LC firing and its relationship to social interaction is unknown. One possibility is that tonic firing may increase in the presence of social partners; it is also possible that phasic bursts may accompany specific social events. We used chronic

Indexed as

Locus CoeruleusNorepinephrineAnimalsFemaleHumansMaternal BehaviorMiceNeuronsReproducibility of ResultsNorepinephrineelectrophysiologyfiber photometrylocus coeruleusmaternal behaviornoradrenaline

Identifiers

PMID35273081
PMCPMC8985872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.