Evidence map›Paper›PMID 35273036›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2022

Influence of Previous Disease-Modifying Drug Exposure on T-Lymphocyte Dynamic in Patients With Multiple Sclerosis Treated With Ocrelizumab.

Doriana Landi, Alfonso Grimaldi, Francesca Bovis, Marta Ponzano, Roberta Fantozzi, Fabio Buttari, Elisabetta Signoriello, Giacomo Lus, Matteo Lucchini, Massimiliano Mirabella and 7 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Assessing Sustained B-Cell Depletion and Disease Activity in a French Multiple Sclerosis Cohort Treated by Long-Term IV Anti-CD20 Antibody Therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Article
  6. Ocrelizumab Impairs the Phenotype and Function of Memory CD8Neurology(R) neuroimmunology & neuroinflammation · 2023
    Article
  7. Article
  8. Acute Effects of Ocrelizumab Infusion in Multiple Sclerosis Patients.International journal of molecular sciences · 2022
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Doriana LandiFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.ORCID 0000-0002-3309-8417
Alfonso GrimaldiFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.
Francesca BovisFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.ORCID 0000-0002-3823-4000
Marta PonzanoFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.
Roberta FantozziFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.
Fabio ButtariFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.
Elisabetta SignorielloFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.
Giacomo LusFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.
Matteo LucchiniFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.ORCID 0000-0002-0447-2297
Massimiliano MirabellaFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.
Maria CellerinoFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.ORCID 0000-0002-4359-9872
Matilde IngleseFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.
Gaia ColaFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.
Carolina Gabri NicolettiFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.
Giorgia MataluniFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.
Diego CentonzeFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.
Girolama Alessandra MarfiaFrom the Multiple Sclerosis Research and Clinical Unit (D.L., A.G., G.C., C.G.N., G.M., G.A.M.); Department of Systems Medicine (D.L., G.C., C.G.N., G.M., D.C., G.A.M.), Tor Vergata University, Rome; Department of Health Sciences (DISSAL) (F. Bovis, M.P.), University of Genoa; Unit of Neurology and Neurorehabilitation (R.F., F. Buttari, D.C., G.A.M.), IRCCS Neuromed, Pozzilli; Multiple Sclerosis Center (E.S., G.L.), Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples; Multiple Sclerosis Center (M.L., M.M.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome; Università Cattolica Del Sacro Cuore (M.L., M.M.), CERSM, Rome; Department of Neuroscience (M.C., M.I.), Rehabilitation, Maternal and Child Health (DINOGMI), University of Genoa; and IRCCS Ospedale Policlinico San Martino (M.I.), Genoa, Italy.
Dr. M.G.R. Educational and Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesTo investigate the longitudinal dynamic of lymphocyte subsets during treatment with ocrelizumab (OCR) in patients with multiple sclerosis (PwMS).

methodsA multicenter retrospective study was conducted in 161 PwMS starting treatment with OCR grouped in naive (naive, n = 40), switching from fingolimod (FTY, n = 52), and switching from other immunomodulating drugs (other, n = 69). Mean lymphocyte subset (total, CD3

resultsMean total, CD3 DISCUSSION: OCR per se exerts a modest depleting effect on T cells that seems rather due to a carryover phenomenon of previous therapies, particularly FTY. These data may help in the overall evaluation of the risk/benefit profile of treatment sequencing.

Indexed as

LymphopeniaMultiple SclerosisAntibodies, Monoclonal, HumanizedFingolimod HydrochlorideHumansRetrospective StudiesAntibodies, Monoclonal, HumanizedFingolimod Hydrochlorideocrelizumab

Identifiers

PMID35273036
PMCPMC9005049
OpenAlexW4220753301

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