Evidence map›Paper›PMID 35273033›Full record

Trial reportThe European respiratory journal2022

Dynamic contrast enhanced MRI for the evaluation of lung perfusion in idiopathic pulmonary fibrosis.

Luis A Torres, Kristine E Lee, Gregory P Barton, Andrew D Hahn, Nathan Sandbo, Mark L Schiebler, Sean B Fain

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Luis A TorresDept of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.ORCID 0000-0003-1948-3500
Kristine E LeeDept of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.ORCID 0000-0002-9102-4627
Gregory P BartonDept of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.ORCID 0000-0001-7471-5488
Andrew D HahnDept of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.ORCID 0000-0002-0246-2108
Nathan SandboDept of Medicine, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.ORCID 0000-0002-5732-4589
Mark L SchieblerDept of Medicine, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.ORCID 0000-0002-9120-5428
Sean B FainDept of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA sean-fain@uiowa.edu.ORCID 0000-0001-5461-0646
University of Wisconsin–Madison · USUniversity of Iowa · US

Funding

Thr Role of Pin1 in AirwayP01HL088594 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2008 to 2017
$21.0M
Protein carbohydrate interactions in the pathophysiology of asthma exacerbationsR01HL080414 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John V Fahy · 2005 to 2026
$9.2M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
Wisconsin Allergy Research Training (WISCART) ProgramT32AI007635 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern, DANIEL J JACKSON · 2000 to 2026
$6.5M
MRI Phenotyping of Severe BPD and Prediction of OutcomesR01HL146689 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI JASON C WOODS · 2019 to 2026
$4.6M
MRI methods for high resolution imaging of the lungR01HL136965 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSON, KEVIN MICHAEL, LARSON, PEDER ERIC ZUFALL · 2018 to 2021
$2.7M
XeBox-E10 Gas Polarizer for Functional MRI of Pediatric Lung DiseaseS10OD016394 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI FAIN, SEAN BEDILION · 2013 to 2013
$600k
NHLBI NIH HHS P01 HL088594NHLBI NIH HHS R01 HL080414NHLBI NIH HHS R01 HL126771NHLBI NIH HHS R01 HL136965NHLBI NIH HHS R01 HL146689NIAID NIH HHS T32 AI007635NIH HHS S10 OD016394
6 · The paper itself

Abstract

backgroundThe objective of this work was to apply quantitative and semiquantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) methods to evaluate lung perfusion in idiopathic pulmonary fibrosis (IPF).

methodsIn this prospective trial 41 subjects, including healthy control and IPF subjects, were studied using DCE-MRI at baseline. IPF subjects were then followed for 1 year; progressive IPF (IPF

resultsDCE-MRI identified regional perfusion differences between control and IPF subjects using first moment transit time (FMTT), contrast uptake slope and pulmonary blood flow (PBF) (p≤0.05), while global averages did not. FMTT was shorter for IPF

conclusionsGlobal analysis obscures regional changes in pulmonary haemodynamics in IPF using DCE-MRI in IPF. Decreased FMTT may be a candidate marker for IPF progression.

Indexed as

Idiopathic Pulmonary FibrosisCarbon MonoxideHumansLungMagnetic Resonance ImagingPerfusionProspective StudiesVital CapacityCarbon Monoxide

Identifiers

PMID35273033
PMCPMC10015995
OpenAlexW4220994073

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.