Evidence map›Paper›PMID 35273026›Full record

ReviewClinical medicine (London, England)2022

The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia.

Cheng-Hock Toh, Guozheng Wang, Alan L Parker

Open access · diamondAbstract readReview
In one paragraph

Review in Clinical medicine (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. How to approach acute thrombosis and thrombocytopenia.Clinical medicine (London, England) · 2023
    Review
  8. Potential mechanisms of vaccine-induced thrombosis.European journal of internal medicine · 2022
    Review
  9. Health means more than just healthcare.Clinical medicine (London, England) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Cheng-Hock TohUniversity of Liverpool, Liverpool, UK c.h.toh@liverpool.ac.uk.
Guozheng WangUniversity of Liverpool, Liverpool, UK.
Alan L ParkerCardiff University School of Medicine, Cardiff, UK.
University of Liverpool · GBCardiff University · GB

Funding

British Heart Foundation PG/16/65/32313
6 · The paper itself

Abstract

In the new science emanating from the COVID-19 pandemic, effective vaccine development has made a huge difference and saved countless lives. Vaccine roll-out led to the identification of rare cases of severe thrombotic and thrombocytopenic problems in some recipients. This apparent coupling of thrombosis with haemorrhagic potentiation might seem baffling but the ensuing clinical investigation rapidly shed important light on its molecular mechanism. This review outlines the current understanding on the role of adenovirus-based platforms, the immunogenic triggers and the immunothrombotic response underlying vaccine-induced immune thrombotic thrombocytopenia.

Indexed as

COVID-19ThrombocytopeniaThrombosisVaccinesCOVID-19 VaccinesHumansPandemicsSARS-CoV-2COVID-19 VaccinesVaccinesadenovirus vaccinesCOVID-19Fc-gamma-RIIaplatelet factor-4vaccine-induced immune thrombotic thrombocytopenia

Identifiers

PMID35273026
PMCPMC8966812
OpenAlexW4221004243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.