Observational studyFertility and sterility2022
Undetectable viral RNA in follicular fluid, cumulus cells, and endometrial tissue samples in SARS-CoV-2-positive women.
Observational study in Fertility and sterility, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Detection of SARS-CoV-2 in Follicular Fluid and Cumu-lus-oocyte-complexes From COVID-19 Patients During Controlled Ovarian Stimulation for ICSI Treatment
Retrospective Study of COVID-19 on Reproductive Function and Assisted Reproductive Technology Pregnancy Outcome in China
The Effects and Underlying Mechanisms of Novel Coronavirus Infection on Reproductive Function and Assisted Pregnancy Outcome
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Impact of SARS-CoV-2 infection on clinical outcomes ofFrontiers in endocrinology · 2023Pooled it
- The Impact of Long COVID on the Female Reproductive System: A Narrative Review.International journal of molecular sciences · 2026Review
- Menstrual vulnerability to acute systemic stress: evidence from 884 women after COVID-19 infection.BMC women's health · 2026Article
- Effect of SARS-CoV-2 infection on pregnant outcomes after embryo transfer: a multicenter retrospective study.BMC pregnancy and childbirth · 2026Article
- Maternal acute SARS-CoV-2 infection impairs preimplantation embryo development and reprograms the early offspring hematopoietic system.Cell discovery · 2025Article
- The association between pregnancy outcomes of frozen thawed embryo transfers and previous SARS-CoV-2 infections.Scientific reports · 2025Article
- The Clinical and Metabolic Profiles in Menstrual Changes Among Reproductive-Aged Women Post-COVID-19.MedComm · 2025Article
- Effect of SARS-CoV-2 infection on human embryonic development and clinical outcomes: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Effects of SARS-CoV-2 infection during IVF treatment on embryo morphokinetics and pregnancy outcomes after fresh transfer: a prospective cohort study.Reproductive biology and endocrinology : RB&E · 2025Article
- SARS-CoV-2 compromises blastocyst quality by modifying the ovarian microenvironment.Signal transduction and targeted therapy · 2025Article
- The biological and psychological impact of the Coronavirus disease-19 pandemic on the characteristics of the menstrual cycle.Journal of the Turkish German Gynecological Association · 2024Article
- Transcriptomic responses of cumulus granulosa cells to SARS-CoV-2 infection during controlled ovarian stimulation.Apoptosis : an international journal on programmed cell death · 2024Article
- The impact and inflammatory characteristics of SARS-CoV-2 infection during ovarian stimulation on the outcomes of assisted reproductive treatment.Frontiers in endocrinology · 2024Article
- Article
- Effects of SARS-CoV-2 infection on embryological outcomes in assisted reproductive technology during the Omicron epidemic.Journal of ovarian research · 2023Article
- Impacts of the COVID-19 pandemic on Chinese assisted reproductive technology institutions and human sperm banks: reflections in the post-pandemic era.Journal of health, population, and nutrition · 2023Review
- Association of SARS-CoV-2 Infection During Controlled Ovarian Stimulation With Oocyte- and Embryo-Related Outcomes.JAMA network open · 2023Article
- The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study.Science China. Life sciences · 2023Article
- Effects of COVID-19 Infection and Vaccination on the Female Reproductive System: A Narrative ReviewBalkan medical journal · 2023Review
- SARS-CoV-2, fertility and assisted reproduction.Human reproduction update · 2023Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the presence of viral RNA in the follicular fluid, cumulus cells, and endometrial tissue samples in SARS-CoV-2-positive women undergoing assisted reproductive technology (ART).
designProspective, single-center, observational study.
settingTertiary hospital. PATIENT(S): A total of 16 patients undergoing transvaginal oocyte retrieval who had a positive SARS-CoV-2 RNA test <48 hours before the procedure. All patients underwent the retrieval between September 2020 and June 2021 and used in vitro fertilization or intracytoplasmic sperm injection. All embryos were vitrified to avoid conception during SARS-CoV-2 infection. INTERVENTION(S): Follicular fluid aspirated during oocyte retrieval, cumulus cells, and endometrial samples were analyzed for SARS-CoV-2 RNA using the RealStar SARS-CoV-2 RT-PCR-Kit1.0. MAIN OUTCOME MEASURE(S): The primary outcome parameter was the detection of viral RNA in the follicular fluid, cumulus cells, and endometrial cells. Fertilization rate, embryo developmental potential, and clinical outcome after frozen embryo transfer were secondary outcome parameters. RESULT(S): Samples from 16 patients were analyzed. Cycle threshold values of <40 were considered positive. All samples were negative for SARS-CoV-2 viral RNA. No inflammatory lesions of the endometrium were identified histologically. Fertilization rate, embryo development, and clinical outcomes after embryo transfer were reassuring. CONCLUSION(S): In women infected with SARS-CoV-2 who underwent ART, viral RNA was undetectable in the follicular fluid, cumulus cells, and endometrium. Caution is warranted in view of the small sample size, and the risk of SARS-CoV-2 affecting the embryo via ART cannot be ruled out. Adequate counseling of women and couples undergoing ART is crucial in parallel with further research on the effect of exposure of the early human embryo to SARS-CoV-2. CLINICAL TRIAL REGISTRATION NUMBER: NCT04425317.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.