Evidence map›Paper›PMID 35272709›Full record

ArticleTranslational neurodegeneration2022

Autologous treatment for ALS with implication for broad neuroprotection.

Daehwan Kim, Subin Kim, Ashley Sung, Neetika Patel, Nathan Wong, Michael J Conboy, Irina M Conboy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational neurodegeneration, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daehwan KimDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA.
Subin KimDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA.
Ashley SungDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA.
Neetika PatelDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA.
Nathan WongDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA.
Michael J ConboyDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA.
Irina M ConboyDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA. iconboy@berkeley.edu.ORCID 0000-0002-4276-0644

Funding

Identifying signatures of brain aging through heterochronic blood exchangeR01AG071787 · NIA · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MESSERSMITH, PHILLIP B, MOURRAIN, PHILIPPE · 2021 to 2025
$2.3M
New Generation Blood Exchange Devices for Enhancing Tissue Regeneration and HealthR01HL139605 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI ARAN, KIANA, CONBOY, IRINA M · 2018 to 2021
$1.6M
Treatment of Duchenne Muscular Dystrophy with Cas9 Protein Complexed to Gold NanoparticlesR01EB023776 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONBOY, IRINA M, MURTHY, NIREN · 2017 to 2020
$1.4M
NHLBI NIH HHS R01 HL139605NIA NIH HHS R01 AG071787NIBIB NIH HHS R01 EB023776
6 · The paper itself

Abstract

backgroundAmyotrophic lateral sclerosis (ALS) is characterized by a progressive loss of motor neurons (MNs), leading to paralysis, respiratory failure and death within 2-5 years of diagnosis. The exact mechanisms of sporadic ALS, which comprises 90% of all cases, remain unknown. In familial ALS, mutations in superoxide dismutase (SOD1) cause 10% of cases.

methodsALS patient-derived human-induced pluripotent stem cells (ALS hiPSCs, harboring the SOD1

resultsThe secretome of PSCs including the ALS patient iPSCs was neuroprotective in the H

conclusionsThis work introduces and mechanistically characterizes a new biologic for treating ALS and other complex neurodegenerative diseases.

Indexed as

Amyotrophic Lateral SclerosisAnimalsHumansHydrogen PeroxideMiceMice, TransgenicNeuroprotectionParalysisSuperoxide DismutaseSuperoxide Dismutase-1Hydrogen PeroxideSuperoxide DismutaseSuperoxide Dismutase-1Amyotrophic lateral sclerosisNeurodegenerationPluripotent stem cellsSecretomeSOD1 mutation

Identifiers

PMID35272709
PMCPMC8915496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.