Evidence map›Paper›PMID 35272698›Full record

Observational studyEuropean journal of medical research2022

Serum cystatin C, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, klotho and fibroblast growth factor-23 in the early prediction of acute kidney injury associated with sepsis in a Chinese emergency cohort study.

Yuanyuan Pei, Guangping Zhou, Pengfei Wang, Fang'e Shi, Xiaolu Ma, Jihong Zhu

Open access · goldAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yuanyuan PeiEmergency Department, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, China.
Guangping ZhouEmergency Department, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, China.
Pengfei WangEmergency Department, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, China.
Fang'e ShiEmergency Department, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, China.
Xiaolu MaEmergency Department, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, China.
Jihong ZhuEmergency Department, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, China. zhujihong64@sina.com.
Peking University · CNPeking University People's Hospital · CN

Funding

The research and development fund of Peking University People's Hospital RDY2018-15
6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) is a common and critical complication of sepsis, and is associated with unacceptable morbidity and mortality. Current diagnostic criteria for AKI was insensitive for early detection. Novel biomarkers including cystatin C, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), klotho and fibroblast growth factor-23 (FGF-23) can predict AKI earlier and allow immediate interventions. We aimed to determine the diagnostic performance of these biomarkers for detecting AKI in sepsis patients.

methodsThis prospective observational study was conducted between May 2018 and November 2020, enrolling 162 sepsis patients eventually. The AKI was defined in accordance with 2012 KDIGO criteria and we divided patients into non-AKI (n = 102) and AKI (n = 60) groups. Serum levels of several AKI biomarkers were detected by ELISA. The relationship between biomarker levels on admission of AKI was analyzed and discrimination performances comparison were performed.

resultsAKI incidence was up to 37.0% (60/162) during hospitalization. Compared with non-AKI group, both serum cystatin C, KIM-1, NGAL and FGF-23 were significantly elevated at admission in septic AKI patients. The areas under the receiver operating curves demonstrated that serum cystatin C had modest discriminative powers for predicting AKI after sepsis, and cystatin C combined with serum creatinine in the prediction of septic AKI increased the diagnostic sensitivity prominently.

conclusionSerum cystatin C, KIM-1, NGAL and FGF-23 levels were both increased in septic AKI patients. Our study provided reliable evidence that cystatin C solely and combined with serum creatinine may accurately and sensitively predict septic AKI of patients on admission.

Indexed as

Early DiagnosisAcute Kidney InjuryAgedBiomarkersChinaCystatin CEnzyme-Linked Immunosorbent AssayFemaleFibroblast Growth Factor-23Hepatitis A Virus Cellular Receptor 1HumansKlotho ProteinsLipocalin-2MalePredictive Value of TestsProspective StudiesBiomarkersCystatin CFibroblast Growth Factor-23HAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1Klotho ProteinsKL protein, humanLipocalin-2Acute kidney injuryBiomarkersCystatin CKIM-1Sepsis

Identifiers

PMID35272698
PMCPMC8915476
OpenAlexW4220888395

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.