Evidence map›Paper›PMID 35272627›Full record

ArticleBMC infectious diseases2022

Long-term immune responses in patients with confirmed novel coronavirus disease-2019: a 9-month prospective cohort study in Shanghai, China.

Xiaohuan Gong, Peng Cui, Huanyu Wu, Hao Pan, Zheng Teng, Fang Yuan, Shenghua Mao, Dechuan Kong, Ruobing Han, Xue Zhao and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. SARS-CoV-2 antibodies persist up to 12 months after natural infection in healthy employees working in non-medical contact-intensive professions.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 2 institutions in 1 country.

Xiaohuan Gong *Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Peng Cui *Department of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Huanyu Wu *Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Hao Pan *Department of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Zheng Teng *Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Fang YuanDepartment of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Shenghua MaoDepartment of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Dechuan KongDepartment of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Ruobing HanDepartment of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Xue ZhaoDepartment of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Yaxu ZhengDepartment of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Wenjia XiaoDepartment of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Yiyi ZhuDepartment of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Qiwen FangDepartment of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Sheng LinDepartment of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Bihong JinDepartment of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Ruilin ChuDepartment of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Chenyan JiangDepartment of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Xiao YuDepartment of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Qi QiuDepartment of Infectious Disease Control and Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Yihan LuDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Weibing Wang *Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China. wwb@fudan.edu.cn.
Chen Fu *Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China. fuchen_scdc@126.com.
Xiaodong Sun *Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China. sunxiaodong_scdc@163.com.ORCID http://orcid.org/0000-0002-3522-6718
Shanghai Municipal Center For Disease Control Prevention · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe duration of antibodies against SARS-CoV-2 in Covid-19 patients remains uncertain. Longitudinal serological studies are needed to prevent disease and transmission of the virus.

methodsIn 2020, 414 blood samples were tested, obtained from 157 confirmed Covid-19 patients, in a prospective cohort study in Shanghai.

resultsThe seropositive rate of IgM peaked at 40.5% (17/42) within 1 month after illness onset and then declined. The seropositive rate of IgG was 90.6% (58/64) after 2 months, remained above 85% from 2 to 9 months and was 90.9% (40/44) after 9 months. Generalized estimating equations models suggested that IgM (P < 0.001) but not IgG significantly decreased over time. Age ≥ 40 years (adjusted odds ratio [aOR] 4.531; 95% confidence interval [CI] 1.879-10.932), and cigarette smoking (aOR 0.344; 95% CI 0.124-0.951) were associated with IgG, and age ≥ 40 years (aOR 2.820; 95% CI 1.579-5.036) was associated with IgM. After seroconversion, over 90% and 75.1% of subjects were estimated to remain IgG-positive 220 and 254 days, respectively. Of 1420 self-reported symptoms questionnaires, only 5% reported symptoms 9 months after onset.

conclusionsIn patients with a history of natural infection, anti-SARS-CoV-2 IgG is long-lived, being present for at least 9 months after illness onset. The long duration of natural immunity can mitigate and eliminate Covid-19 and the ongoing pandemic.

Indexed as

COVID-19AdultChinaHumansImmunityImmunoglobulin MProspective StudiesSARS-CoV-2Immunoglobulin MAntibodiesCohort studyCovid-19ImmunitySARS-CoV-2

Identifiers

PMID35272627
PMCPMC8907900
OpenAlexW4220654944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.