ArticleNeuroImage2022
Large-scale differences in functional organization of left- and right-handed individuals using whole-brain, data-driven analysis of connectivity.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Machine Learning and Prediction in Fetal, Infant, and Toddler Neuroimaging: A Review and Primer.Biological psychiatry · 2023Pooled it
- Sex differences in brain homotopic co-activations: a meta-analytic study.Brain structure & function · 2022Pooled it
- Replicability of Functional Brain Networks: A Study Through the Lens of Seven Resting-State Networks.Human brain mapping · 2026Article
- External validation improves generalizability, replicability and reproducibility in predictive models for neuroimaging.Nature methods · 2026Review
- Frontal Vulnerability versus Temporal Resilience within the Core Language Network: Neuro-compensatory Mechanisms Underline Differential Language Aging Trajectories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Altered amplitudes of low-frequency fluctuations in primary open angle glaucoma patients: a resting-state fMRI study.International journal of ophthalmology · 2026Article
- Genetic risk predicts adolescent mood pathology via sexual differentiation of brain function and physiological aging.Nature communications · 2025Article
- Article
- Connectome-based predictive modeling of early and chronic psychosis symptoms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Increased functional connectivity of motor regions and dorsolateral prefrontal cortex in musicians with focal hand dystonia.Journal of neurology · 2025Article
- Brain handedness associations depend on how and when handedness is measured.Scientific reports · 2025Article
- Randomized prenatal and postnatal nutrient supplementation shows no long-term impact on cortical gray matter in Ghanaian children.Frontiers in human neuroscience · 2025Article
- Exploring functional connectivity in clinical and data-driven groups of preterm and term adults.Brain communications · 2025Article
- Changes in glucose metabolism in essential tremor: within and beyond the cerebello-thalamo-cortical circuit.Brain communications · 2025Article
- Differences in spatiotemporal dynamics for processing specific semantic categories: An EEG study.Scientific reports · 2024Article
- Asymmetry in Atypical Parkinsonian Syndromes-A Review.Journal of clinical medicine · 2024Review
- Nonparametric Statistical Inference via Metric Distribution Function in Metric Spaces.Journal of the American Statistical Association · 2024Article
- Functional MRI Lateralization [M1] of dlPFC and Implications for Transcranial Magnetic Stimulation (TMS) Targeting.Diagnostics (Basel, Switzerland) · 2023Article
- A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults.Journal of affective disorders · 2022Article
- Leveraging edge-centric networks complements existing network-level inference for functional connectomes.NeuroImage · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Handedness influences differences in lateralization of language areas as well as dominance of motor and somatosensory cortices. However, differences in whole-brain functional connectivity (i.e., functional connectomes) due to handedness have been relatively understudied beyond pre-specified networks of interest. Here, we compared functional connectomes of left- and right-handed individuals at the whole brain level. We explored differences in functional connectivity of previously established regions of interest, and showed differences between primarily left- and primarily right-handed individuals in the motor, somatosensory, and language areas using functional connectivity. We then proceeded to investigate these differences in the whole brain and found that the functional connectivity of left- and right-handed individuals are not specific to networks of interest, but extend across every region of the brain. In particular, we found that connections between and within the cerebellum show distinct patterns of connectivity. To put these effects into context, we show that the effect sizes associated with handedness differences account for a similar amount of individual differences in the connectome as sex differences. Together these results shed light on regions of the brain beyond those traditionally explored that contribute to differences in the functional organization of left- and right-handed individuals and underscore that handedness effects are neurobiologically meaningful in addition to being statistically significant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.