Evidence map›Paper›PMID 35272151›Full record

ArticleJournal of the mechanical behavior of biomedical materials2022

Mechanical characterization and adhesive properties of a dental adhesive modified with a polymer antibiotic conjugate.

Camila Sabatini, Russell J Aguilar, Ziwen Zhang, Steven Makowka, Abhishek Kumar, Megan M Jones, Michelle B Visser, Mark Swihart, Chong Cheng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Camila SabatiniDepartment of Restorative Dentistry, University at Buffalo, The State University of New York, Buffalo, NY, 14214, USA. Electronic address: cs252@buffalo.edu.
Russell J AguilarDepartment of Restorative Dentistry, University at Buffalo, The State University of New York, Buffalo, NY, 14214, USA; Department of Oral Biology, University at Buffalo, The State University of New York, Buffalo, NY, 14214, USA. Electronic address: rcaguila@buffalo.edu.
Ziwen ZhangDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA. Electronic address: ziwenzha@buffalo.edu.
Steven MakowkaDepartment of Restorative Dentistry, University at Buffalo, The State University of New York, Buffalo, NY, 14214, USA. Electronic address: smakowka@buffalo.edu.
Abhishek KumarDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA. Electronic address: akumar37@buffalo.edu.
Megan M JonesDepartment of Oral Biology, University at Buffalo, The State University of New York, Buffalo, NY, 14214, USA. Electronic address: meganste@buffalo.edu.
Michelle B VisserDepartment of Oral Biology, University at Buffalo, The State University of New York, Buffalo, NY, 14214, USA. Electronic address: mbvisser@buffalo.edu.
Mark SwihartDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA. Electronic address: swihart@buffalo.edu.
Chong ChengDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA. Electronic address: ccheng8@buffalo.edu.
University at Buffalo, State University of New York · USBuffalo State University · US

Funding

Polymer-Antibiotic Conjugates as Antibacterial Additives for Dental ResinsR21DE028437 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI CHENG, CHONG, SABATINI, CAMILA · 2019 to 2020
$434k
NIDCR NIH HHS R21 DE028437
6 · The paper itself

Abstract

This study is a follow up investigation on recent work by our group demonstrating synthesis, release and strong antibacterial character of resins modified with penicillin V (PV)-based polymer-antibiotic conjugates (PACs). Here, we aimed to evaluate the mechanical, bonding, and other relevant biomedical properties of a commercial adhesive resin modified with PV-PAC. Single Bond Plus (SB+) was modified with PAC containing 1.8 wt% conjugated PV. Adhesive resins were bonded to dentin from extracted human molars and restorative resin added. Beams of cross-sectional area of 0.9 ± 0.1 mm (Kutsch and Young, 2011) (n = 20) were obtained from the molars and tested for micro-tensile bond strength (μTBS) at 24 h and 4 months. For cohesive strength, hourglass beams (10 × 2 × 1 mm; n = 10) were assessed for ultimate tensile strength (UTS), beam-shaped specimens (25x2x2 mm; n = 10) evaluated for flexural strength and modulus (FS/FM) via three-point bending, and cylindrical specimens (3 × 2 mm; n = 10) assessed for ultimate compressive strength (UCS). For surface micro-hardness (MH), cylindrical specimens (3 × 2 mm; n = 6) were assessed before and after an EtOH challenge. The degree of conversion (DC) (5 × 1 mm; n = 6) was determined based on changes in absorbance ratio between peaks at ∼1637 cm

Indexed as

Dental BondingDentin-Bonding AgentsAdhesivesAnti-Bacterial AgentsComposite ResinsDentinHumansMaterials TestingPolymersResin CementsSurface PropertiesTensile StrengthWaterAdhesivesAnti-Bacterial AgentsComposite ResinsDentin-Bonding AgentsPolymersResin CementsWaterAntibacterial adhesive resinBond strengthMechanical propertiesOn-demand releasePolymer antibiotic conjugateSecondary caries

Identifiers

PMID35272151
PMCPMC9662750
OpenAlexW4214916004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.