Evidence map›Paper›PMID 35271957›Full record

ReviewBiological psychology2022

Amygdala-driven apnea and the chemoreceptive origin of anxiety.

Justin S Feinstein, Dylan Gould, Sahib S Khalsa

Abstract readReview
In one paragraph

Review in Biological psychology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Role of the Amygdala in the Complex Relationship Between Sleep and Anxiety.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Difficult-to-Treat Anxiety: A Neurocomputational Framework.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025
    Review
  6. Article
  7. Astrocytes in Rodent Anxiety-Related Behavior: Role of Calcium and Beyond.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Sensing, feeling and regulating: investigating the association of focal brain damage with voluntary respiratory and motor control.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
  13. Metacognition as a window into subjective affective experience.Psychiatry and clinical neurosciences · 2024
    Review
  14. Article
  15. Article
  16. Carbon dioxide and MAPK signalling: towards therapy for inflammation.Cell communication and signaling : CCS · 2023
    Review
  17. Review
  18. Article
  19. Review
  20. Piecing together the puzzle of emotional consciousness.Neuroscience of consciousness · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Justin S FeinsteinLaureate Institute for Brain Research, Tulsa, OK 74136, USA; University of Tulsa, Oxley College of Health Sciences, Tulsa, OK 74104, USA; University of Iowa, Department of Neurology, Iowa City, IA 52242, USA. Electronic address: feinstein.float@gmail.com.
Dylan GouldLaureate Institute for Brain Research, Tulsa, OK 74136, USA.
Sahib S KhalsaLaureate Institute for Brain Research, Tulsa, OK 74136, USA; University of Tulsa, Oxley College of Health Sciences, Tulsa, OK 74104, USA.

Funding

The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Maëlle Camille Marie Gueguen · 2017 to 2026
$23.7M
A neurocomputational assay of gastrointestinal interoception in anorexia nervosaR01MH127225 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI KHALSA, SAHIB S., PAULUS, MARTIN P. · 2021 to 2025
$3.2M
Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia NervosaK23MH112949 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI KHALSA, SAHIB · 2017 to 2021
$994k
NIGMS NIH HHS P20 GM121312NIMH NIH HHS K23 MH112949NIMH NIH HHS R01 MH127225
6 · The paper itself

Abstract

Although the amygdala plays an important part in the pathogenesis of anxiety and generation of exteroceptive fear, recent discoveries have challenged the directionality of this brain-behavior relationship with respect to interoceptive fear. Here we highlight several paradoxical findings including: (1) amygdala lesion patients who experience excessive fear and panic following inhalation of carbon dioxide (CO

Indexed as

ApneaCarbon DioxideAmygdalaAnxietyAnxiety DisordersHumansCarbon DioxideBrainstemCO(2)FearInteroceptionPanicRespirationSuffocation alarm

Identifiers

PMID35271957
PMCPMC10227885

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.