Evidence map›Paper›PMID 35271850›Full record

ArticleThe Journal of biological chemistry2022

Prion protein with a mutant N-terminal octarepeat region undergoes cobalamin-dependent assembly into high-molecular weight complexes.

Nathalie Daude, Agnes Lau, Ilaria Vanni, Sang-Gyun Kang, Andrew R Castle, Serene Wohlgemuth, Lyudmyla Dorosh, Holger Wille, Maria Stepanova, David Westaway

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Nathalie DaudeCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada.
Agnes LauCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada.
Ilaria VanniDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Sang-Gyun KangCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada.
Andrew R CastleCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada.
Serene WohlgemuthCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada.
Lyudmyla DoroshFaculty of Engineering - Electrical & Computer Engineering Department, University of Alberta, Edmonton, Canada.
Holger WilleCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada; Department of Biochemistry, University of Alberta, Edmonton, Canada.
Maria StepanovaFaculty of Engineering - Electrical & Computer Engineering Department, University of Alberta, Edmonton, Canada.
David WestawayCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada. Electronic address: david.westaway@ualberta.ca.
University of Alberta · CAIstituto Superiore di Sanità · IT

Funding

CIHR MOP123525CIHR PS165980
6 · The paper itself

Abstract

The cellular prion protein (PrP

Indexed as

Prion DiseasesPrion ProteinsPrionsAnimalsCopperMolecular WeightMutationProtein BindingVitamin B 12CopperPrion ProteinsPrionsVitamin B 12cobalaminconformational changeglycoproteinoligomerplasma membraneprionsporadic diseasevitamin B12

Identifiers

PMID35271850
PMCPMC9010764
OpenAlexW4221071817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.