Evidence map›Paper›PMID 35271754›Full record

ReviewCancer science2022

Neuroendocrine tumor theranostics.

Yasushi Ichikawa, Noritoshi Kobayashi, Shoko Takano, Ikuma Kato, Keigo Endo, Tomio Inoue

Open access · goldAbstract readReview
In one paragraph

Review in Cancer science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yasushi IchikawaDepartment of Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.ORCID https://orcid.org/0000-0002-7866-2907
Noritoshi KobayashiDepartment of Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.ORCID https://orcid.org/0000-0002-9181-3722
Shoko TakanoDepartment of Radiation Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Ikuma KatoDepartment of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.ORCID https://orcid.org/0000-0002-7731-9509
Keigo EndoKyoto College of Medical Science, Kyoto, Japan.
Tomio InoueDepartment of Radiation Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yokohama City University · JPKyoto College of Medical Science · JPShonan Kamakura General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Theranostics is a term coined by combining the words "therapeutics" and "diagnostics," referring to single chemical entities developed to deliver therapy and diagnosis simultaneously. Neuroendocrine tumors are rare cancers that occur in various organs of the body, and they express neuroendocrine factors such as chromogranin A and somatostatin receptor. Somatostatin analogs bind to somatostatin receptor, and when combined with diagnostic radionuclides, such as gamma-emitters, are utilized for diagnosis of neuroendocrine tumor. Somatostatin receptor scintigraphy when combined with therapeutic radionuclides, such as beta-emitters, are effective in treating neuroendocrine tumor as peptide receptor radionuclide therapy. Somatostatin receptor scintigraphy and peptide receptor radionuclide therapy are some of the most frequently used and successful theranostics for neuroendocrine tumor. In Japan, radiopharmaceuticals are regulated under a complex law system, creating a significant drug lag, which is a major public concern. It took nearly 10 years to obtain the approval for somatostatin receptor scintigraphy and peptide receptor radionuclide therapy use by the Japanese government. In 2021,

Indexed as

Neuroendocrine TumorsHumansPositron-Emission TomographyPrecision MedicineRadioisotopesRadionuclide ImagingRadiopharmaceuticalsReceptors, Somatostatincopper dotatate CU-64RadioisotopesRadiopharmaceuticalsReceptors, Somatostatinneuroendocrine tumorpeptide receptor radionuclide therapysomatostatin analogsomatostatin receptor scintigraphytheranostics

Identifiers

PMID35271754
PMCPMC9207370
OpenAlexW4220910186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.