Evidence map›Paper›PMID 35271704›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Severe Acute Respiratory Syndrome Coronavirus 2 Delta Vaccine Breakthrough Transmissibility in Alachua County, Florida.

Brittany Rife Magalis, Shannan Rich, Massimiliano S Tagliamonte, Carla Mavian, Melanie N Cash, Alberto Riva, Simone Marini, David Moraga Amador, Yanping Zhang, Jerne Shapiro and 12 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Does the COVID-19 Vaccination Reduce the Risk to Transmit SARS-CoV-2 to Others?Advances in experimental medicine and biology · 2024
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 1 country.

Brittany Rife MagalisEmerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-6088-4651
Shannan RichDepartment of Epidemiology, University of Florida, Gainesville, Florida, USA.
Massimiliano S TagliamonteEmerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
Carla MavianEmerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
Melanie N CashEmerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
Alberto RivaInterdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida, USA.
Simone MariniDepartment of Pathology, University of Florida, Gainesville, Florida, USA.
David Moraga AmadorInterdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida, USA.
Yanping ZhangInterdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida, USA.
Jerne ShapiroDepartment of Epidemiology, University of Florida, Gainesville, Florida, USA.
Amelia HorineFlorida Department of Health, Alachua County, Gainesville, Florida, USA.
Petr StarostikDepartment of Pathology, University of Florida, Gainesville, Florida, USA.
Maura PierettiBayCare Laboratories LLC, Tampa, Florida, USA.
Samantha VegaBayCare Laboratories LLC, Tampa, Florida, USA.
Ana Paula LacombeUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Jessica SalinasUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Mario StevensonUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Paul MyersFlorida Department of Health, Alachua County, Gainesville, Florida, USA.
J Glenn MorrisEmerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
Michael LauzardoEmerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
Mattia ProsperiDepartment of Epidemiology, University of Florida, Gainesville, Florida, USA.
Marco SalemiEmerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
University of Florida · USFlorida Department of Health · USUniversity of Miami · USBayCare Health System · US

Funding

A Phylodynamic Artificial Intelligence framework to predict evolution of SARS-CoV-2 variants of concern in Immunocompromised persons with HIV (PhAI-CoV)R01AI170187 · NIAID · UNIVERSITY OF FLORIDA · PI MARIA LUISA ALCAIDE, Deborah Lynne Jones · 2022 to 2026
$3.7M
Forecasting trajectories of HIV transmission networks with a novel phylodynamic and deep learning frameworkR01AI145552 · NIAID · UNIVERSITY OF FLORIDA · PI Simone Marini, Mattia Prosperi · 2020 to 2026
$3.6M
NIAID NIH HHS R01 AI170187
6 · The paper itself

Abstract

backgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant has caused a dramatic resurgence in infections in the United Sates, raising questions regarding potential transmissibility among vaccinated individuals.

methodsBetween October 2020 and July 2021, we sequenced 4439 SARS-CoV-2 full genomes, 23% of all known infections in Alachua County, Florida, including 109 vaccine breakthrough cases. Univariate and multivariate regression analyses were conducted to evaluate associations between viral RNA burden and patient characteristics. Contact tracing and phylogenetic analysis were used to investigate direct transmissions involving vaccinated individuals.

resultsThe majority of breakthrough sequences with lineage assignment were classified as Delta variants (74.6%) and occurred, on average, about 3 months (104 ± 57.5 days) after full vaccination, at the same time (June-July 2021) of Delta variant exponential spread within the county. Six Delta variant transmission pairs between fully vaccinated individuals were identified through contact tracing, 3 of which were confirmed by phylogenetic analysis. Delta breakthroughs exhibited broad viral RNA copy number values during acute infection (interquartile range, 1.2-8.64 Log copies/mL), on average 38% lower than matched unvaccinated patients (3.29-10.81 Log copies/mL, P < .00001). Nevertheless, 49% to 50% of all breakthroughs, and 56% to 60% of Delta-infected breakthroughs exhibited viral RNA levels above the transmissibility threshold (4 Log copies/mL) irrespective of time after vaccination.

conclusionsDelta infection transmissibility and general viral RNA quantification patterns in vaccinated individuals suggest limited levels of sterilizing immunity that need to be considered by public health policies. In particular, ongoing evaluation of vaccine boosters should specifically address whether extra vaccine doses curb breakthrough contribution to epidemic spread.

Indexed as

COVID-19Viral VaccinesFloridaHumansPhylogenyRNA, ViralSARS-CoV-2VaccinationRNA, ViralViral Vaccinescontact tracingdeltaFloridaphylogeneticSARS-CoV2transmissionvaccination

Identifiers

PMID35271704
PMCPMC9617581
OpenAlexW4220814349

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.