Evidence map›Paper›PMID 35271351›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2022

Multiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia.

Brian J Sandri, Jonathan Kim, Gabriele R Lubach, Eric F Lock, Candace Guerrero, LeeAnn Higgins, Todd W Markowski, Pamela J Kling, Michael K Georgieff, Christopher L Coe and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Anemia, Iron Supplementation, and the Brain.Clinics in perinatology · 2023
    Review
  5. Article
  6. Bayesian predictive modeling of multi-source multi-way data.Computational statistics & data analysis · 2023
    Article
  7. Article
  8. Article
  9. Modifiable contributing factors to COVID-19: A comprehensive review.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Brian J SandriDivision of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0003-4935-6502
Jonathan KimDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Gabriele R LubachHarlow Center for Biological Psychology, University of Wisconsin, Madison, Wisconsin.
Eric F LockDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Candace GuerreroDepartment of Biochemistry, Molecular Biology, & Biophysics, University of Minnesota, Minneapolis, Minnesota.
LeeAnn HigginsDepartment of Biochemistry, Molecular Biology, & Biophysics, University of Minnesota, Minneapolis, Minnesota.
Todd W MarkowskiDepartment of Biochemistry, Molecular Biology, & Biophysics, University of Minnesota, Minneapolis, Minnesota.
Pamela J KlingDivision of Neonatology, Department of Pediatrics, University of Wisconsin, Madison, Wisconsin.
Michael K GeorgieffDivision of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Christopher L CoeHarlow Center for Biological Psychology, University of Wisconsin, Madison, Wisconsin.
Raghavendra B RaoDivision of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-6089-5972
University of Minnesota · USUniversity of Wisconsin–Madison · US

Funding

STATISTICAL COREP01HD039386 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOZOFF, BETSY · 2001 to 2011
$14.0M
Detection and Correction of Iron Deficiency Induced Abnormal Brain MetabolismR01HD089989 · NICHD · UNIVERSITY OF MINNESOTA · PI COE, CHRISTOPHER L, GEORGIEFF, MICHAEL K. · 2017 to 2021
$2.7M
Novel Medical Food for Treating Infant Anemia and Iron Deficiency in the CNSR01HD080201 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI COE, CHRISTOPHER L · 2014 to 2018
$2.1M
Gestational Stress and Impaired Iron Homeostasis in the Young InfantR01HD057064 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI COE, CHRISTOPHER L · 2009 to 2013
$1.6M
Identifying Biomarkers from Multi-source, Multi-way DataR01GM130622 · NIGMS · UNIVERSITY OF MINNESOTA · PI LOCK, ERIC F · 2019 to 2023
$1.5M
NICHD NIH HHS P01 HD039386NICHD NIH HHS R01 HD057064NICHD NIH HHS R01 HD080201NICHD NIH HHS R01 HD089989NIGMS NIH HHS R01 GM130622
6 · The paper itself

Abstract

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cerebrospinal fluid (CSF) biomarkers of ID-induced metabolic dysfunction are concordant in the pre/early anemic stage of ID before anemia in a nonhuman primate model of infantile iron deficiency anemia (IDA). ID (

Indexed as

AnemiaAnemia, Iron-DeficiencyIron DeficienciesAnimalsBiomarkersHumansIronMacaca mulattaProteomicsBiomarkersIroncerebrospinal fluidiron deficiency anemiametabolomicsneurological functionproteomics

Identifiers

PMID35271351
PMCPMC9054343
OpenAlexW4220655263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.