ArticleScience (New York, N.Y.)2022
Programmable molecular transport achieved by engineering protein motors to move on DNA nanotubes.
Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 76 citations in OpenAlex.
- A computational framework for designing micron-scale crisscross DNA megastructures.Nature communications · 2026Article
- A multiple-encrypted DNA device for secure communication.Science advances · 2026Article
- Clocked stepping of an artificial protein walker along a DNA track.Nature nanotechnology · 2026Article
- Stepping ahead toward custom-designed autonomous motor proteins.Nature nanotechnology · 2026Article
- Programming DNA machines to move.Nature reviews. Chemistry · 2026Review
- Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026Review
- The mechanochemical cycle of reactive full-length human dynein 1.Nature structural & molecular biology · 2025Article
- Impact of physiological ionic strength and crowding on kinesin-1 motility.Cell structure and function · 2025Article
- Morphology remodelling and membrane channel formation in synthetic cells via reconfigurable DNA nanorafts.Nature materials · 2025Article
- Rational engineering of DNA-nanoparticle motor with high speed and processivity comparable to motor proteins.Nature communications · 2025Article
- Engineering Dynein Motors to Move on DNA Nanotube Tracks.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Lateral nanoarchitectonics from nano to life: ongoing challenges in interfacial chemical science.Chemical science · 2024Review
- Session commentaries: synthetic and constructive biology.Biophysical reviews · 2024Review
- A geometrical theory of gliding motility based on cell shape and surface flow.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The motive forces in DNA-enabled nanomachinery.iScience · 2024Review
- Collective Molecular Machines: Multidimensionality and Reconfigurability.Nano-micro letters · 2024Review
- Triggered contraction of self-assembled micron-scale DNA nanotube rings.Nature communications · 2024Article
- DNA as a universal chemical substrate for computing and data storage.Nature reviews. Chemistry · 2024Review
- Motility of an autonomous protein-based artificial motor that operates via a burnt-bridge principle.Nature communications · 2024Article
- Self-assembly of DNA parallel double-crossover motifs.Nanoscale · 2024Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular transport is the basis of microscale logistics within cells and is powered by biomolecular motors. Mimicking transport for in vitro applications has been widely studied; however, the inflexibility in track design and control has hindered practical applications. Here, we developed protein-based motors that move on DNA nanotubes by combining a biomolecular motor dynein and DNA binding proteins. The new motors and DNA-based nanoarchitectures enabled us to arrange the binding sites on the track, locally control the direction of movement, and achieve multiplexed cargo transport by different motors. The integration of these technologies realized microscale cargo sorters and integrators that automatically transport molecules as programmed in DNA sequences on a branched DNA nanotube. Our system should provide a versatile, controllable platform for future applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.