ArticleScience (New York, N.Y.)2022
Local connectivity and synaptic dynamics in mouse and human neocortex.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers.
0numbers the graph read from it
0cells of the map it votes in
193citing papers in PubMed
39.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
193 citing papers in PubMed, 370 citations in OpenAlex.
- Strong and localized recurrence controls the dimensionality of neural activity across brain areas.Nature neuroscience · 2026Article
- Pyramidal cell types and circuit organization of the mouse insular cortex reveal functional specializations.Nature neuroscience · 2026Article
- Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits.Nature communications · 2026Article
- Clustering and Principal Component Analysis as Distinct Computational Regimes of a Biologically Motivated Neural Circuit.Brain sciences · 2026Article
- Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex.Science advances · 2026Article
- Synaptic Development of Fine Spatial Scale Organization of Neuronal Orientation Tuning in Mouse Primary Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
- DuBois-Reymond prize lecture 2024: Multi-neuron patch-clamp to uncover the neuronal and synaptic physiology in the human neocortex.Pflugers Archiv : European journal of physiology · 2026Article
- A computational theory of short-term synaptic plasticity: synapses learn to tell time.Research square · 2026Article
- Cortical PV and VIP interneurons similarly influence SST neuron output despite distinct unitary properties.Communications biology · 2026Article
- A mean-field model of neural networks with PV and SOM interneurons reveals connectivity-based mechanisms of gamma oscillations.PLoS computational biology · 2026Article
- Context-dependent effects of SOM neurons to enhance the responses of corticocollicular neurons to repetitive sounds.iScience · 2026Article
- Glutamatergic neuron-tumor synapses shape human glioblastoma cell states through radial glia plasticity.bioRxiv : the preprint server for biology · 2026Article
- Cell-type-specific parallel pathways in the canonical cortical microcircuit.bioRxiv : the preprint server for biology · 2026Article
- Deep-learning-assisted simulation of a cortical circuit: integrating anatomy, physiology and function.bioRxiv : the preprint server for biology · 2026Article
- Psilocybin reshapes cortical inhibition through selective interneuron recruitment.bioRxiv : the preprint server for biology · 2026Article
- A multimodal approach for visualizing and identifying electrophysiological cell types in vivo.Nature communications · 2026Article
- Orbitofrontal cortex drives predictive filtering of sensory responses.Nature neuroscience · 2026Article
- Feature-tuned synaptic inputs to somatostatin interneurons drive context-dependent processing.Neuron · 2026Article
- Cellular and subcellular specialization enables biology-constrained deep learning.Cell reports · 2026Article
- Article
133 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
89 authors at 3 institutions in 1 country.
Luke Campagnola *Allen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-2959-1284
Stephanie C Seeman *Allen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-3894-1992
Thomas ChartrandAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-7093-8681
Lisa KimAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-3811-8680
Alex HoggarthAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-7634-7989
Clare GamlinAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-5975-7003
Shinya ItoAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-5529-223X
Jessica TrinhAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-5064-8898
Pasha DavoudianAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-5096-7610
Cristina RadaelliAllen Institute for Brain Science, Seattle, WA, USA.
Mean-Hwan KimAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-8065-4631
Travis HageAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6125-2768
Thomas BraunByte Physics, Berlin, Germany.ORCID 0000-0002-1416-2065
Lauren AlfilerAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-4847-7900
Julia AndradeAllen Institute for Brain Science, Seattle, WA, USA.
Phillip BohnAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-1378-3449
Rachel DalleyAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-7461-7845
Alex HenryAllen Institute for Brain Science, Seattle, WA, USA.
Sara KebedeAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3775-1583
Mukora AliceAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-8431-985X
David SandmanAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-6968-4859
Grace WilliamsAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-8463-2886
Rachael LarsenAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-0178-003X
Corinne TeeterAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3519-9203
Tanya L DaigleAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-9700-8452
Kyla BerryAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-0632-6322
Nadia DotsonAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-3414-3176
Rachel EnstromAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-0100-927X
Melissa GorhamAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6770-9474
Madie HuppAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-7444-5286
Samuel Dingman LeeAllen Institute for Brain Science, Seattle, WA, USA.
Kiet NgoAllen Institute for Brain Science, Seattle, WA, USA.
Philip R NicovichAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-8517-4469
Lydia PotekhinaAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-8879-7920
Shea RansfordAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-6093-0806
Amanda GaryAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6397-1520
Jeff GoldyAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-5140-6922
Delissa McMillenAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3413-4424
Trangthanh PhamAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-4738-5062
Michael TieuAllen Institute for Brain Science, Seattle, WA, USA.
La'Akea SivertsAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-1385-086X
Miranda WalkerAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3767-1591
Colin FarrellAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-3487-3064
Martin SchroedterAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-0211-4226
Cliff SlaughterbeckAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-2789-9071
Charles CobbThe Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA, USA.ORCID 0000-0001-7688-4293
Richard EllenbogenDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Ryder P GwinnEpilepsy Surgery and Functional Neurosurgery, Swedish Neuroscience Institute, Seattle, WA, USA.ORCID 0000-0002-5849-7975
C Dirk KeeneDepartment of Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5291-1469
Andrew L KoDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6253-9891
Jeffrey G OjemannDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Daniel L SilbergeldDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Daniel CareyAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-4459-1960
Tamara CasperAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-1638-3651
Kirsten CrichtonAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-7869-1492
Michael ClarkAllen Institute for Brain Science, Seattle, WA, USA.
Nick DeeAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-2831-9254
Lauren EllingwoodAllen Institute for Brain Science, Seattle, WA, USA.
Jessica GloeAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-8343-3423
Matthew KrollAllen Institute for Brain Science, Seattle, WA, USA.
Josef SulcAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-4928-7183
Herman TungAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-0812-3318
Katherine WadhwaniAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-1518-4290
Krissy BrounerAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-5790-7154
Tom EgdorfAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-9059-8904
Michelle MaxwellAllen Institute for Brain Science, Seattle, WA, USA.
Medea McGrawAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-5267-489X
Christina Alice PomAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-9057-040X
Augustin RuizAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-8361-5152
Jasmine BombenAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-3965-5373
David FengAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-4920-8123
Nika HejaziniaAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-0365-7062
Shu ShiAllen Institute for Brain Science, Seattle, WA, USA.
Aaron SzaferAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-0019-8470
Wayne WakemanAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3693-3609
John PhillipsAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-1080-7556
Amy BernardAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-2540-1153
Luke EspositoAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3565-9126
Florence D D'OraziAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-7354-4725
Susan SunkinAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-9893-3834
Kimberly SmithAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3142-1970
Bosiljka TasicAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6861-4506
Anton ArkhipovAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-1106-8310
Staci SorensenAllen Institute for Brain Science, Seattle, WA, USA.
Ed LeinAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-9012-6552
Christof KochAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-6482-8067
Gabe MurphyAllen Institute for Brain Science, Seattle, WA, USA.
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-0326-5878
Tim JarskyAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-4399-539X
Allen Institute for Brain Science · USUniversity of Washington · USSwedish Medical Center · US
Funding
Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ZENG, HONGKUI · 2017 to 2021
$64.7MUniversity of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Thomas J. Grabowski · 2020 to 2026
$29.0MA multimodal atlas of human brain cell typesU01MH114812 · NIMH · ALLEN INSTITUTE · PI LEIN, ED · 2017 to 2021
$19.2MEstablishing a Comprehensive and Standardized Cell Type Characterization PlatformU01MH105982 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, ZENG, HONGKUI · 2014 to 2016
$5.1MCell class- or type-specific viruses for brain-wide labeling and neural circuit examinationRF1MH121274 · NIMH · ALLEN INSTITUTE · PI TASIC, BOSILJKA · 2019 to 2019
$2.6MTemporal, cell type- and locus-specific epigenetic control in transgenic miceR01DA036909 · NIDA · ALLEN INSTITUTE · PI TASIC, BOSILJKA · 2013 to 2017
$2.3MNIA NIH HHS P30 AG066509NIDA NIH HHS R01 DA036909NIMH NIH HHS RF1 MH121274NIMH NIH HHS U01 MH105982NIMH NIH HHS U01 MH114812NIMH NIH HHS U19 MH114830
Abstract
We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and human cortex. The dynamics of excitatory synapses align with the postsynaptic cell subclass, whereas inhibitory synapse dynamics partly align with presynaptic cell subclass but with considerable overlap. Synaptic properties are heterogeneous in most subclass-to-subclass connections. The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass. In the human cortex, excitatory-to-excitatory synaptic dynamics are distinct from those in the mouse cortex and vary with depth across layers 2 and 3.
Indexed as
Neural PathwaysSynaptic TransmissionAdultAnimalsDatasets as TopicExcitatory Postsynaptic PotentialsFemaleHumansInhibitory Postsynaptic PotentialsMaleMiceMice, TransgenicModels, NeurologicalNeocortexNeuronsSynapses
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.