Evidence map›Paper›PMID 35271203›Full record

ArticleSensors (Basel, Switzerland)2022

Investigation of Red Blood Cells by Atomic Force Microscopy.

Viktoria Sergunova, Stanislav Leesment, Aleksandr Kozlov, Vladimir Inozemtsev, Polina Platitsina, Snezhanna Lyapunova, Alexander Onufrievich, Vyacheslav Polyakov, Ekaterina Sherstyukova

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

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  9. Force spectroscopy reveals membrane fluctuations and surface adhesion of extracellular nanovesicles impact their elastic behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Viktoria SergunovaLaboratory of Biophysics of Cell Membranes under Critical State, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, Russia.ORCID 0000-0002-8425-0845
Stanislav LeesmentNT-MDT Spectrum Instruments, Proezd 4922, 4/3 Zelenograd, 124460 Moscow, Russia.
Aleksandr KozlovDepartment of Medical and Biological Physics, Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Vladimir InozemtsevLaboratory of Biophysics of Cell Membranes under Critical State, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, Russia.ORCID 0000-0002-4693-5624
Polina PlatitsinaInstitute of Biotechnical Systems and Technologies National Research"MIET", Shokin Sq., Build.1, 124498 Zelenograd, Russia.
Snezhanna LyapunovaLaboratory of Biophysics of Cell Membranes under Critical State, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, Russia.
Alexander OnufrievichFederal State Budgetary Institution "N.N. Burdenko Main Military Clinical Hospital" of the Ministry of Defense of the Russian Federation, Hospital Sq., Build. 3, 105094 Moscow, Russia.
Vyacheslav PolyakovNT-MDT Spectrum Instruments, Proezd 4922, 4/3 Zelenograd, 124460 Moscow, Russia.
Ekaterina SherstyukovaLaboratory of Biophysics of Cell Membranes under Critical State, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, Russia.ORCID 0000-0002-9962-6315
V.A. Negovsky Scientific Research Institute of General Reanimatology · RUResearch and Production Complex Technological Centre · RUSechenov University · RUNational Research University of Electronic Technology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, much research is devoted to the study of biological objects using atomic force microscopy (AFM). This method's resolution is superior to the other non-scanning techniques. Our study aims to further emphasize some of the advantages of using AFM as a clinical screening tool. The study focused on red blood cells exposed to various physical and chemical factors, namely hemin, zinc ions, and long-term storage. AFM was used to investigate the morphological, nanostructural, cytoskeletal, and mechanical properties of red blood cells (RBCs). Based on experimental data, a set of important biomarkers determining the status of blood cells have been identified.

Indexed as

ErythrocytesMicroscopy, Atomic Forceatomic force microscopycytoskeletonimagingmembrane stiffnessmorphologynanostructurered blood cells

Identifiers

PMID35271203
PMCPMC8914789
OpenAlexW4220724319

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.