Evidence map›Paper›PMID 35270665›Full record

ArticleInternational journal of environmental research and public health2022

Efficient Production of Naringin Acetate with Different Acyl Donors via Enzymatic Transesterification by Lipases.

Yesol Baek, Seungmee Lee, Jemin Son, Taek Lee, Jong-Min Oh, Sang Hun Lee, Hyun Uk Kim, Sang Woo Seo, Si Jae Park, Hah Young Yoo and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Yesol BaekDepartment of Chemical Engineering, Kwangwoon University, Seoul 01897, Korea.
Seungmee LeeDepartment of Chemical Engineering, Kwangwoon University, Seoul 01897, Korea.
Jemin SonDepartment of Chemical Engineering, Kwangwoon University, Seoul 01897, Korea.
Taek LeeDepartment of Chemical Engineering, Kwangwoon University, Seoul 01897, Korea.
Jong-Min OhDepartment of Electronic Materials Engineering, Kwangwoon University, Seoul 01897, Korea.ORCID 0000-0001-6303-2876
Sang Hun LeeDepartment of Chemical and Biological Engineering, Hanbat National University, Daejeon 34158, Korea.ORCID 0000-0002-8629-8842
Hyun Uk KimDepartment of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.ORCID 0000-0001-7224-642X
Sang Woo SeoSchool of Chemical and Biological Engineering, Institute of Chemical Process, Seoul National University, Seoul 08826, Korea.ORCID 0000-0002-7434-7053
Si Jae ParkDivision of Chemical Engineering and Materials Science, Ewha Womans University, Seoul 03760, Korea.
Hah Young YooDepartment of Chemical Engineering, Kwangwoon University, Seoul 01897, Korea.ORCID 0000-0001-6701-6654
Chulhwan ParkDepartment of Chemical Engineering, Kwangwoon University, Seoul 01897, Korea.ORCID 0000-0003-1148-7881
Kwangwoon University · KRHanbat National University · KREwha Womans University · KRKorea Advanced Institute of Science and Technology · KRSangmyung University · KRSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Naringin, one of the citrus flavonoids and known as a natural antioxidant, has limited bioavailability owing to its low stability and solubility. However, naringin esters formed via acylation have recently been reported to possess improved physical and chemical properties. The development of these compounds has a great potential in the food, cosmetic and pharmaceutical industries, but low conversion and productivity are barriers to industrial applications. This study aimed to improve the conversion of naringin acetate, which is formed via the enzymatic reaction between naringin and an acyl donor. An optimal reaction condition was determined by evaluating the effect of various variables (enzyme type, enzyme concentration, acyl donor, molar ratio of reactants, reaction temperature, and solvent) on the synthesis of naringin acetate. The optimal condition was as follows: 3 g/L of Lipozyme TL IM, molar ratio of 1:5 (naringin:acyl donor), reaction temperature of 40 °C, and acetonitrile as the reaction solvent. Under this condition, the maximum conversion to naringin acetate from acetic anhydride and vinyl acetate was achieved at approximately 98.5% (8 h) and 97.5% (24 h), respectively. Compared to the previously reported values, a high conversion was achieved within a short time, confirming the commercial potential of the process.

Indexed as

FlavanonesEstersFlavonoidsSolventsEstersFlavanonesFlavonoidsnaringinSolventsacylationantioxidantenzymatic synthesisflavonoidflavonoid acetateflavonoid esterlipasenaringintransesterification

Identifiers

PMID35270665
PMCPMC8910296
OpenAlexW4214867418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.