Evidence map›Paper›PMID 35270411›Full record

SynthesisInternational journal of environmental research and public health2022

Efficacy of Treatments in Nonarteritic Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis.

Krisztina Lantos, Zsuzsa Réka Dömötör, Nelli Farkas, Szabolcs Kiss, Zsolt Szakács, András Garami, Gábor Varga, László Lujber, Reem Kanaan, Péter Hegyi and 2 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
28.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Krisztina LantosDepartment of Ophthalmology, Medical School, University of Pécs, 7632 Pécs, Hungary.
Zsuzsa Réka DömötörDepartment of Ophthalmology, Medical School, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-3561-2539
Nelli FarkasInstitute of Bioanalysis, Medical School, University of Pécs, 7624 Pécs, Hungary.
Szabolcs KissDoctoral School of Clinical Medicine, University of Szeged, 6720 Szeged, Hungary.ORCID 0000-0001-5032-866X
Zsolt SzakácsInstitute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0002-7035-941X
András GaramiInstitute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0003-2493-0571
Gábor VargaDepartment of Oral Biology, Faculty of Dentistry, Semmelweis University, 1089 Budapest, Hungary.ORCID 0000-0002-5506-8198
László LujberDepartment of Otorhinolaryngology, Medical School, University of Pécs, 7621 Pécs, Hungary.
Reem KanaanDepartment of Public Health Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Péter HegyiInstitute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Gergely FehérDepartment of Primary Health Care, Medical School, University of Pécs, 7624 Pécs, Hungary.
Valéria GaálDepartment of Ophthalmology, Medical School, University of Pécs, 7632 Pécs, Hungary.ORCID 0000-0003-3905-1414
University of Pecs · HUSemmelweis University · HUUniversity of Debrecen · HUUniversity of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonarteritic Anterior Ischemic Optic Neuropathy (NAION) is the second most common cause of optic nerve-related permanent visual loss in adults.

aimWe aimed to analyze the efficacy of the noninvasive and minimally invasive therapeutic options of NAION.

methodsWe performed a systematic literature search in MEDLINE, EMBASE, and CENTRAL from inception to 10 June 2019 to identify the studies that report on the effect of different therapies on visual acuity (VA) and visual field (VF). Weighted mean difference (WMD) with 95% confidence interval (CI) was calculated for these outcomes. The efficacy of steroids was investigated in quantitative, oxygen, steroid plus erythropoietin (EPO), levodopa/carbidopa, memantine, and heparin-induced extracorporeal LDL/fibrinogen precipitation (HELP) therapies and other therapeutic modalities in qualitative synthesis.

resultsThirty-two studies were found to be eligible. We found that steroid therapy compared to control did not improve VA (

conclusionOur systematic review did not reveal any effective treatment. Further investigations are needed to find therapy for NAION.

Indexed as

Optic Neuropathy, IschemicAdultHumansLevodopaMemantineOxygenSteroidsVisual AcuityLevodopaMemantineOxygenSteroidsmeta-analysisNAIONnonarteritic ischemic optic neuropathy

Identifiers

PMID35270411
PMCPMC8910678
OpenAlexW4214685542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.