ArticleInternational journal of molecular sciences2022
Hyperglycemia Promotes Endothelial Cell Senescence through AQR/PLAU Signaling Axis.
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Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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28citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The biomedical application of inorganic metal nanoparticles in aging and aging-associated diseases.Journal of advanced research · 2025Pooled it
- Inflammation in atherosclerosis: Drivers, mechanisms and therapies.Acta pharmaceutica Sinica. B · 2026Review
- The Role of Cellular Senescence in Oral Health and Disease.International journal of molecular sciences · 2026Review
- Ophiopogon japonicus-derived plant exosomes: a promising strategy for blocking the progression of diabetic vasculopathy to myocardial infarction.BMC complementary medicine and therapies · 2026Article
- Integrated Transcriptomics and Experimental Validation Reveal That Ellagic Acid Alleviates Fuchs Endothelial Corneal Dystrophy via PLAU/NF-κB Signaling.Investigative ophthalmology & visual science · 2026Article
- Traditional Chinese medicine in diabetes management: a comprehensive review of mechanisms and therapeutic potential.Frontiers in endocrinology · 2026Review
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- A Global Transcriptomic Analysis Reveals Body Weight-Specific Molecular Responses to Chronic Orange Juice Consumption in Healthy Individuals.Molecular nutrition & food research · 2025Article
- Dietary Citrate Restores Age-Related Endothelial Cell Mitochondrial Dysfunction and Alleviates Atherosclerosis.Aging cell · 2025Article
- SGLT2 inhibitors as a novel senotherapeutic approach.npj aging · 2025Review
- Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics?Biomolecules · 2025Review
- Association between descending aorta wall thickness or wall area and cardiovascular disease risk factors in cardiovascular disease-free patients: a study based on water-calcium material decomposition and subtraction-based computed tomography dark-blood imaging.Quantitative imaging in medicine and surgery · 2025Article
- The Therapeutic Effect and Mechanism of Traditional Chinese Medicine in Type 2 Diabetes Mellitus and Its Complications.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Topical Application of miR-200b-3p by Poloxamer 407-Based Hydrogel Accelerates Diabetic Wound Healing.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Sodium Tanshinone IIA Sulfonate alleviates vascular senescence in diabetic mice by modulating the A20-NFκB-NLRP3 inflammasome-catalase pathway.Scientific reports · 2024Article
- A multi-omics study to monitor senescence-associated secretory phenotypes of Alzheimer's disease.Annals of clinical and translational neurology · 2024Article
- Article
- High Glucose Promotes and Aggravates the Senescence and Dysfunction of Vascular Endothelial Cells in Women with Hyperglycemia in Pregnancy.Biomolecules · 2024Article
- Traditional Chinese medicine and its active substances reduce vascular injury in diabetes via regulating autophagic activity.Frontiers in pharmacology · 2024Review
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Yiqi WanAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Zhirui LiuAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Andong WuAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Abdul Haseeb KhanAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.ORCID 0000-0003-4845-7774
Ying ZhuAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.ORCID 0000-0003-4259-5201
Shuangjin DingAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Xueer LiAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Ya ZhaoAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Ximo DaiAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Jin ZhouAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Jiankun LiuAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Yuanyuan LiAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Xueting GongAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Man LiuAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.
Xiao-Li TianAging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Jiangxi Key Laboratory of Human Aging, Nanchang University, Nanchang 330031, China.ORCID 0000-0002-0868-7025
Nanchang University · CN
Funding
Jiangxi Science and Technology Department 20192ACB70002, 20181ACB20017, and 20181BCD40001Ministry of Science and Technology 2020YFC2002900National Natural Science Foundation of China 81630034
Abstract
Hyperglycemia is reported to accelerate endothelial cell senescence that contributes to diabetic complications. The underlying mechanism, however, remains elusive. We previously demonstrated
Indexed as
Biological PhenomenaDiabetes Mellitus, Type 2HyperglycemiaAnimalsCaenorhabditis elegansCells, CulturedCellular SenescenceHumansHuman Umbilical Vein Endothelial CellsRatsAQRdiabetesendothelial senescenceinflammationPLAU
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.