Evidence map›Paper›PMID 35269995›Full record

ReviewInternational journal of molecular sciences2022

Blood Thiol Redox State in Chronic Kidney Disease.

Maria Lisa Garavaglia, Daniela Giustarini, Graziano Colombo, Francesco Reggiani, Silvia Finazzi, Marta Calatroni, Lucia Landoni, Nicola Marcello Portinaro, Aldo Milzani, Salvatore Badalamenti and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Observational
  2. Article
  3. Combination of Policosanol (RaydelPharmaceuticals (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Synergistic Effect of Banaba Leaf Extract and Policosanol (RaydelPharmaceuticals (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. The Hydroalcoholic Extract ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Maria Lisa GaravagliaDepartment of Biosciences (Department of Excellence 2018-2022), Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy.ORCID 0000-0002-4118-1659
Daniela GiustariniDepartment of Biotechnology, Chemistry and Pharmacy (Department of Excellence 2018-2022), University of Siena, Via A. Moro 2, 53100 Siena, Italy.ORCID 0000-0003-4929-5316
Graziano ColomboDepartment of Biosciences (Department of Excellence 2018-2022), Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy.ORCID 0000-0001-8663-735X
Francesco ReggianiNephrology and Dialysis Unit, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy.
Silvia FinazziNephrology and Dialysis Unit, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy.
Marta CalatroniNephrology and Dialysis Unit, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy.
Lucia LandoniDepartment of Biosciences (Department of Excellence 2018-2022), Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy.
Nicola Marcello PortinaroDepartment of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, 20133 Milan, Italy.
Aldo MilzaniDepartment of Biosciences (Department of Excellence 2018-2022), Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy.
Salvatore BadalamentiNephrology and Dialysis Unit, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy.
Ranieri RossiDepartment of Biotechnology, Chemistry and Pharmacy (Department of Excellence 2018-2022), University of Siena, Via A. Moro 2, 53100 Siena, Italy.
Isabella Dalle-DonneDepartment of Biosciences (Department of Excellence 2018-2022), Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy.ORCID 0000-0001-7098-6213
University of Milan · ITHumanitas University · ITIRCCS Humanitas Research Hospital · ITUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thiols (sulfhydryl groups) are effective antioxidants that can preserve the correct structure of proteins, and can protect cells and tissues from damage induced by oxidative stress. Abnormal levels of thiols have been measured in the blood of patients with moderate-to-severe chronic kidney disease (CKD) compared to healthy subjects, as well as in end-stage renal disease (ESRD) patients on haemodialysis or peritoneal dialysis. The levels of protein thiols (a measure of the endogenous antioxidant capacity inversely related to protein oxidation) and

Indexed as

Kidney Failure, ChronicRenal Insufficiency, ChronicAntioxidantsBiomarkersHumansOxidation-ReductionOxidative StressProteinsSulfhydryl CompoundsAntioxidantsBiomarkersProteinsSulfhydryl Compoundschronic kidney diseaseend-stage renal diseasehaemodialysisperitoneal dialysisprotein thiolation indexprotein thiolsS-thiolated proteins

Identifiers

PMID35269995
PMCPMC8911004
OpenAlexW4220918590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.