ArticleInternational journal of molecular sciences2022
Cardiovascular, Metabolic and Inflammatory Changes after Ovariectomy and Estradiol Substitution in Hereditary Hypertriglyceridemic Rats.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Barley sprouts as a modulator of the gut microbiota, influencing glucose and lipid metabolism in ovariectomized female rats fed a high-fat diet.Nutrition research and practice · 2026Article
- Cardiovascular Effects of Early and Postponed Statin Treatment After Ovariectomy in Prediabetic Rat.Physiological research · 2026Article
- 17β-Estradiol Does Not Designate Non-Sex-Specific Early Ventricular Arrhythmia in Acute Myocardial Infarction, in Contrast to C-Reactive Protein.International journal of molecular sciences · 2026Article
- Development and validation of an integrated preclinical model mimicking cardiometabolic risk in postmenopausal female rats.Scientific reports · 2025Article
- Age-dependent neuroinflammation response to voluntary wheel running and Metformin treatment in the frontal cortex of ovariectomized female mice.Scientific reports · 2025Article
- The Benefits of Estradiol on Cognitive Aging in Rats Are Independent From Its Effects on Cardiometabolic Health.Endocrinology · 2025Article
- The Effect of Ovariectomy and Estradiol Substitution on the Metabolic Parameters and Transcriptomic Profile of Adipose Tissue in a Prediabetic Model.Antioxidants (Basel, Switzerland) · 2024Article
- Estrogen receptor alpha mediates 17β-estradiol, up-regulates autophagy and alleviates hydrogen peroxide-induced vascular senescence.Biogerontology · 2023Article
- Hypertension after the Menopause: What Can We Learn from Experimental Studies?Physiological research · 2023Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIf menopause is really independent risk factor for cardiovascular disease is still under debate. We studied if ovariectomy in the model of insulin resistance causes cardiovascular changes, to what extent are these changes reversible by estradiol substitution and if they are accompanied by changes in other organs and tissues.
methodsHereditary hypertriglyceridemic female rats were divided into three groups: ovariectomized at 8th week (
resultsAfter ovariectomy, the strain of abdominal aorta, expression of nitric oxide synthase in abdominal aorta, relative weight of myocardium and of the left ventricle and circulating interleukin-6 decreased; these changes were reversed by estradiol substitution. Interestingly, the content of triglycerides in myocardium did not change after ovariectomy, but significantly increased after estradiol substitution while adiposity index did not change after ovariectomy, but significantly decreased after estradiol substitution.
conclusionVascular and cardiac parameters under study differed in their response to ovariectomy and estradiol substitution. This indicates different effects of ovariectomy and estradiol on different cardiovascular but also extracardiac structures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.