Evidence map›Paper›PMID 35269964›Full record

ArticleInternational journal of molecular sciences2022

Reactive Oxygen Species Cause Exercise-Induced Angina in a Myocardial Ischaemia-Reperfusion Injury Model.

Xiaohang Wang, Hirosato Kanda, Takeshi Tsujino, Yoko Kogure, Feng Zhu, Satoshi Yamamoto, Taichi Sakaguchi, Koichi Noguchi, Yi Dai

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiaohang WangDepartment of Cardiovascular Surgery, Hyogo College of Medicine, Nishinomiya 663-8501, Hyogo, Japan.ORCID 0000-0003-0949-2673
Hirosato KandaDepartment of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe 650-8530, Hyogo, Japan.ORCID 0000-0003-2547-9073
Takeshi TsujinoDepartment of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe 650-8530, Hyogo, Japan.
Yoko KogureDepartment of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe 650-8530, Hyogo, Japan.
Feng ZhuDepartment of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe 650-8530, Hyogo, Japan.
Satoshi YamamotoDepartment of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe 650-8530, Hyogo, Japan.ORCID 0000-0001-6408-626X
Taichi SakaguchiDepartment of Cardiovascular Surgery, Hyogo College of Medicine, Nishinomiya 663-8501, Hyogo, Japan.
Koichi NoguchiDepartment of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya 663-8501, Hyogo, Japan.
Yi DaiDepartment of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Kobe 650-8530, Hyogo, Japan.ORCID 0000-0003-1349-9886
Hyogo University of Health Sciences · JPHyogo Medical University · JP

Funding

Hyogo Innovative Challenge Grant of Hyogo College of Medicine and the Chinese Medicine Confucius Institute at Hyogo College of Medicine Research Grants. DY
6 · The paper itself

Abstract

Percutaneous coronary intervention (PCI) effectively treats obstructive coronary artery syndrome. However, 30-40% patients continue to have angina after a successful PCI, thereby reducing patient satisfaction. The mechanisms underlying persistent angina after revascularisation therapy are still poorly understood; hence, the treatment or guideline for post-PCI angina remains unestablished. Thus, this study aimed to investigate the mechanisms underlying effort angina in animals following myocardial ischaemia-reperfusion (I/R) injury. Phosphorylated extracellular signal-regulated kinase (p-ERK), a marker for painful stimulation-induced neuronal activation, was used for the investigation. After a forced treadmill exercise (FTE), the number of p-ERK-expressing neurons increased in the superficial dorsal horn of the I/R model animals. Moreover, FTE evoked hydrogen peroxide (H

Indexed as

Myocardial Reperfusion InjuryPercutaneous Coronary InterventionAngina PectorisAnimalsExtracellular Signal-Regulated MAP KinasesHumansHydrogen PeroxideMiceReactive Oxygen SpeciesExtracellular Signal-Regulated MAP KinasesHydrogen PeroxideReactive Oxygen Speciesangina post PCIexercise-induced cardiac painhydrogen peroxidemyocardial I/R injuryp-ERKTRPA1

Identifiers

PMID35269964
PMCPMC8910887
OpenAlexW4220778579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.