Evidence map›Paper›PMID 35269913›Full record

ArticleInternational journal of molecular sciences2022

Human MicroRNAs Attenuate the Expression of Immediate Early Proteins and HCMV Replication during Lytic and Latent Infection in Connection with Enhancement of Phosphorylated RelA/p65 (Serine 536) That Binds to MIEP.

Yeon-Mi Hong, Seo Yeon Min, Dayeong Kim, Subin Kim, Daekwan Seo, Kyoung Hwa Lee, Sang Hoon Han

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yeon-Mi HongDivision of Infectious Disease, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 06273, Korea.ORCID 0000-0001-8683-1275
Seo Yeon MinDivision of Infectious Disease, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 06273, Korea.
Dayeong KimDivision of Infectious Disease, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 06273, Korea.
Subin KimDivision of Infectious Disease, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 06273, Korea.
Daekwan SeoSeverance Biomedical Science Institute, Yonsei University College of Medicine, Seoul 06273, Korea.
Kyoung Hwa LeeDivision of Infectious Disease, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 06273, Korea.ORCID 0000-0003-0033-1398
Sang Hoon HanDivision of Infectious Disease, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 06273, Korea.ORCID 0000-0002-4278-5198
Yonsei University · KR

Funding

Basic Science Research Program through the National Research Foundation of Korea (NRF), Korean government (Ministry of Education and Ministry of Science and ICT) NRF-2017R1D1A1B03032844, NRF-2019R1F1A1063437"Dongwha" Faculty Research Assistance Program of Yonsei University College of Medicine 6-2015-0176
6 · The paper itself

Abstract

Attenuating the expression of immediate early (IE) proteins is essential for controlling the lytic replication of human cytomegalovirus (HCMV). The human microRNAs (hsa-miRs), miR-200b-3p and miR-200c-3p, have been identified to bind the 3'-untranslated region (3'-UTR) of the mRNA encoding IE proteins. However, whether hsa-miRs can reduce IE72 expression and HCMV viral load or exhibit a crosstalk with the host cellular signaling machinery, most importantly the NF-κB cascade, has not been evaluated. In this study, argonaute-crosslinking and immunoprecipitation-seq revealed that miR-200b-3p and miR-200c-3p bind the 3'-UTR of

Indexed as

Immediate-Early ProteinsLatent InfectionMicroRNAs3' Untranslated RegionsCytomegalovirusHumansSerineTranscription Factor RelA3' Untranslated RegionsImmediate-Early ProteinsMicroRNAsRELA protein, humanSerineTranscription Factor RelAHCMVimmediate early proteinlatent infectionmicroRNAMIEPNF-κBphosphorylationRelA/p65serine 536

Identifiers

PMID35269913
PMCPMC8911160
OpenAlexW4214905312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.