ArticleInternational journal of molecular sciences2022
Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Article
- Review of Antimicrobial Properties of Titanium Dioxide Nanoparticles.International journal of molecular sciences · 2024Review
- Poly(2-Deoxy-2-Methacrylamido-D-Glucose)-Based Complex Conjugates of Colistin, Deferoxamine and Vitamin B12: Synthesis and Biological Evaluation.Pharmaceutics · 2024Article
- Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D.International journal of molecular sciences · 2024Review
- Porous Hydrogels for Immunomodulatory Applications.International journal of molecular sciences · 2024Review
- Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery.Pharmaceutics · 2023Review
- Biopolymers in Drug and Gene Delivery Systems.International journal of molecular sciences · 2023Article
- A pH/enzyme dual responsive PMB spatiotemporal release hydrogel promoting chronic wound repair.Journal of nanobiotechnology · 2023Article
- Polymyxin B Conjugates with Bio-Inspired Synthetic Polymers of Different Nature.International journal of molecular sciences · 2023Article
- Peptide-Based Materials That Exploit Metal Coordination.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The growing number of drug-resistant pathogenic bacteria poses a global threat to human health. For this reason, the search for ways to enhance the antibacterial activity of existing antibiotics is now an urgent medical task. The aim of this study was to develop novel delivery systems for polymyxins to improve their antimicrobial properties against various infections. For this, hybrid core-shell nanoparticles, consisting of silver core and a poly(glutamic acid) shell capable of polymyxin binding, were developed and carefully investigated. Characterization of the hybrid nanoparticles revealed a hydrodynamic diameter of approximately 100 nm and a negative electrokinetic potential. The nanoparticles demonstrated a lack of cytotoxicity, a low uptake by macrophages, and their own antimicrobial activity. Drug loading and loading efficacy were determined for both polymyxin B and E, and the maximal loaded value with an appropriate size of the delivery systems was 450 µg/mg of nanoparticles. Composite materials based on agarose hydrogel were prepared, containing both the loaded hybrid systems and free antibiotics. The features of polymyxin release from the hybrid nanoparticles and the composite materials were studied, and the mechanisms of release were analyzed using different theoretical models. The antibacterial activity against
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.