Evidence map›Paper›PMID 35269882›Full record

ReviewInternational journal of molecular sciences2022

Antimicrobial Peptide Mechanisms Studied by Whole-Cell Deuterium NMR.

Sarika Kumari, Valerie Booth

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  9. A Novel Control Method ofPharmaceutics · 2023
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sarika KumariDepartment of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1C 5S7, Canada.
Valerie BoothDepartment of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1C 5S7, Canada.ORCID 0000-0001-9342-9217
Memorial University of Newfoundland · CA

Funding

National Sciences and Engineering Research Council of Canada 05154
6 · The paper itself

Abstract

Much of the work probing antimicrobial peptide (AMP) mechanisms has focussed on how these molecules permeabilize lipid bilayers. However, AMPs must also traverse a variety of non-lipid cell envelope components before they reach the lipid bilayer. Additionally, there is a growing list of AMPs with non-lipid targets inside the cell. It is thus useful to extend the biophysical methods that have been traditionally applied to study AMP mechanisms in liposomes to the full bacteria, where the lipids are present along with the full complexity of the rest of the bacterium. This review focusses on what can be learned about AMP mechanisms from solid-state NMR of AMP-treated intact bacteria. It also touches on flow cytometry as a complementary method for measuring permeabilization of bacterial lipid membranes in whole bacteria.

Indexed as

Antimicrobial Cationic PeptidesAntimicrobial PeptidesBacteriaCell MembraneDeuteriumLipid BilayersAntimicrobial Cationic PeptidesAntimicrobial PeptidesDeuteriumLipid Bilayersantimicrobial peptides (AMPs)HDPshost defense peptidesMSI-78pexigananwhole cell NMR

Identifiers

PMID35269882
PMCPMC8910884
OpenAlexW4214875483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.