Evidence map›Paper›PMID 35269879›Full record

ArticleInternational journal of molecular sciences2022

Short-Term Pharmacological Induction of Arterial Stiffness and Hypertension with Angiotensin II Does Not Affect Learning and Memory and Cerebral Amyloid Load in Two Murine Models of Alzheimer's Disease.

Jhana O Hendrickx, Elke Calus, Peter Paul De Deyn, Debby Van Dam, Guido R Y De Meyer

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Aging of the Arterial System.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jhana O HendrickxLaboratory of Physiopharmacology, University of Antwerp, 2610 Antwerp, Belgium.ORCID 0000-0001-7639-2926
Elke CalusLaboratory of Neurochemistry and Behaviour, University of Antwerp, 2610 Antwerp, Belgium.
Peter Paul De DeynLaboratory of Neurochemistry and Behaviour, University of Antwerp, 2610 Antwerp, Belgium.ORCID 0000-0002-2228-2964
Debby Van DamLaboratory of Neurochemistry and Behaviour, University of Antwerp, 2610 Antwerp, Belgium.
Guido R Y De MeyerLaboratory of Physiopharmacology, University of Antwerp, 2610 Antwerp, Belgium.ORCID 0000-0003-3848-8702
University of Antwerp · BEUniversity Medical Center Groningen · NL

Funding

Hercules Foundation AUHA/13/03University of Antwerp GOA-BOF: 33931
6 · The paper itself

Abstract

Given the unprecedented rise in the world's population, the prevalence of prominent age-related disorders, like cardiovascular disease and dementia, will further increase. Recent experimental and epidemiological evidence suggests a mechanistic overlap between cardiovascular disease and dementia with a specific focus on the linkage between arterial stiffness, a strong independent predictor of cardiovascular disease, and/or hypertension with Alzheimer's disease. In the present study, we investigated whether pharmacological induction of arterial stiffness and hypertension with angiotensin II (1 µg·kg

Indexed as

Alzheimer DiseaseAmyloidosisCardiovascular DiseasesHypertensionVascular StiffnessAmyloidAmyloid beta-PeptidesAmyloidogenic ProteinsAngiotensin IIAnimalsDisease Models, AnimalMiceAmyloidAmyloid beta-PeptidesAmyloidogenic ProteinsAngiotensin IIAlzheimer’s diseaseamyloidangiotensin IIarterial stiffnesscognitionhypertension

Identifiers

PMID35269879
PMCPMC8910756
OpenAlexW4214702923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.