Evidence map›Paper›PMID 35269767›Full record

ArticleInternational journal of molecular sciences2022

Deficiency in Retinal TGFβ Signaling Aggravates Neurodegeneration by Modulating Pro-Apoptotic and MAP Kinase Pathways.

Christina B Bielmeier, Sabrina I Schmitt, Nikolai Kleefeldt, Stefaniya K Boneva, Anja Schlecht, Mario Vallon, Ernst R Tamm, Jost Hillenkamp, Süleyman Ergün, Andreas Neueder and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  7. Immunology of Retinitis Pigmentosa and Gene Therapy-Associated Uveitis.Cold Spring Harbor perspectives in medicine · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Christina B BielmeierInstitute of Anatomy and Cell Biology, Julius-Maximilians-University Wuerzburg, 97070 Wuerzburg, Germany.
Sabrina I SchmittInstitute of Human Anatomy and Embryology, University of Regensburg, 93053 Regensburg, Germany.
Nikolai KleefeldtDepartment of Ophthalmology, University Hospital Wuerzburg, 97070 Wuerzburg, Germany.
Stefaniya K BonevaEye Center, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0002-9811-2160
Anja SchlechtInstitute of Anatomy and Cell Biology, Julius-Maximilians-University Wuerzburg, 97070 Wuerzburg, Germany.
Mario VallonInstitute of Anatomy and Cell Biology, Julius-Maximilians-University Wuerzburg, 97070 Wuerzburg, Germany.
Ernst R TammInstitute of Human Anatomy and Embryology, University of Regensburg, 93053 Regensburg, Germany.
Jost HillenkampDepartment of Ophthalmology, University Hospital Wuerzburg, 97070 Wuerzburg, Germany.
Süleyman ErgünInstitute of Anatomy and Cell Biology, Julius-Maximilians-University Wuerzburg, 97070 Wuerzburg, Germany.
Andreas NeuederDepartment of Neurology, University of Ulm, 89081 Ulm, Germany.ORCID 0000-0002-2389-5236
Barbara M BraungerInstitute of Anatomy and Cell Biology, Julius-Maximilians-University Wuerzburg, 97070 Wuerzburg, Germany.
University of Würzburg · DEUniversitätsklinikum Würzburg · DEUniversity of Regensburg · DEUniversität Ulm · DEUniversity of Freiburg · DE

Funding

Deutsche Forschungsgemeinschaft BR 4957/3-1Deutsche Forschungsgemeinschaft NE 2372/1-1Helmut Ecker Foundation B.M.B.Jackstädt Foundation B.M.BPRO RETINA Deutschland e.V. B.M.B., S.I.S
6 · The paper itself

Abstract

Transforming growth factor β (TGFβ) signaling has manifold functions such as regulation of cell growth, differentiation, migration, and apoptosis. Moreover, there is increasing evidence that it also acts in a neuroprotective manner. We recently showed that TGFβ receptor type 2 (

Indexed as

Retinal DegenerationTransforming Growth Factor betaAnimalsDisease Models, AnimalEpendymoglial CellsMiceMitogen-Activated Protein KinasesReceptor, Transforming Growth Factor-beta Type IIRetinaMitogen-Activated Protein KinasesReceptor, Transforming Growth Factor-beta Type IITransforming Growth Factor betaferroptosisMAP kinase pathwayneuro-/photoreceptor degenerationretinaretinitis pigmentosaTGFβ signaling

Identifiers

PMID35269767
PMCPMC8910086
OpenAlexW4214675141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.