Evidence map›Paper›PMID 35269748›Full record

ArticleInternational journal of molecular sciences2022

Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives.

Kotone Naitoh, Yuta Orihara, Hiroshi Sakagami, Takumi Miura, Keitaro Satoh, Shigeru Amano, Kenjiro Bandow, Yosuke Iijima, Kota Kurosaki, Yoshihiro Uesawa and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Kotone NaitohFaculty of Science, Josai University, Saitama 250-0295, Japan.
Yuta OriharaFaculty of Science, Josai University, Saitama 250-0295, Japan.
Hiroshi SakagamiResearch Institute of Odontology, Meikai University, Sakado, Saitama 350-0283, Japan.ORCID 0000-0001-8001-2121
Takumi MiuraFaculty of Science, Josai University, Saitama 250-0295, Japan.
Keitaro SatohDivision of Pharmacology, Department of Diagnostics and Therapeutics Sciences, Meikai University School of Dentistry, Saitama 350-0283, Japan.
Shigeru AmanoResearch Institute of Odontology, Meikai University, Sakado, Saitama 350-0283, Japan.
Kenjiro BandowDivision of Biochemistry, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Saitama 350-0283, Japan.ORCID 0000-0002-1362-3034
Yosuke IijimaDepartment of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University, Saitama 350-0283, Japan.
Kota KurosakiDepartment of Medical Molecular Informatics, Meiji Pharmaceutical University, Tokyo 204-8588, Japan.
Yoshihiro UesawaDepartment of Medical Molecular Informatics, Meiji Pharmaceutical University, Tokyo 204-8588, Japan.ORCID 0000-0002-5773-991X
Masashi HashimotoFaculty of Science, Josai University, Saitama 250-0295, Japan.
Hidetsugu WakabayashiFaculty of Science, Josai University, Saitama 250-0295, Japan.
Josai University · JPMeikai University · JPMeiji Pharmaceutical University · JPSocial Insurance Saitama Chuo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVery few papers covering the anticancer activity of azulenes have been reported, as compared with those of antibacterial and anti-inflammatory activity. This led us to investigate the antitumor potential of fifteen 4,6,8-trimethyl azulene amide derivatives against oral malignant cells.

methods4,6,8-Trimethyl azulene amide derivatives were newly synthesized. Anticancer activity was evaluated by tumor-specificity against four human oral squamous cell carcinoma (OSCC) cell lines over three normal oral cells. Neurotoxicity was evaluated by cytotoxicity against three neuronal cell lines over normal oral cells. Apoptosis induction was evaluated by Western blot and cell cycle analyses.

resultsAmong fifteen derivatives, compounds

conclusionsCompounds

Indexed as

Antineoplastic AgentsCarcinoma, Squamous CellMouth NeoplasmsNeurotoxicity SyndromesAmidesApoptosisAzulenesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMolecular StructureReceptors, Cytoplasmic and NuclearAmidesAntineoplastic AgentsazuleneAzulenesReceptors, Cytoplasmic and Nuclear4,6,8-trimethyl azulene amidecaspase 3cell cyclehormone receptormolecular shapeneurotoxicityNFκBoral cancerQASRtumor-specificity

Identifiers

PMID35269748
PMCPMC8910578
OpenAlexW4214520930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.