Evidence map›Paper›PMID 35269717›Full record

ArticleInternational journal of molecular sciences2022

Characterization of Recruited Mononuclear Phagocytes following Corneal Chemical Injury.

Ricardo Lamy, Marie Wolf, Claudia Bispo, Selene M Clay, Siyu Zheng, Finn Wolfreys, Peipei Pan, Matilda F Chan

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ricardo LamyDepartment of Ophthalmology, University of California, San Francisco, CA 94158, USA.
Marie WolfDepartment of Ophthalmology, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-2207-9664
Claudia BispoUCSF Parnassus Flow Cytometry Core Facility, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-4936-058X
Selene M ClayDepartment of Ophthalmology, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-7204-9570
Siyu ZhengDepartment of Ophthalmology, University of California, San Francisco, CA 94158, USA.
Finn WolfreysDepartment of Ophthalmology, University of California, San Francisco, CA 94158, USA.
Peipei PanDepartment of Ophthalmology, University of California, San Francisco, CA 94158, USA.
Matilda F ChanDepartment of Ophthalmology, University of California, San Francisco, CA 94158, USA.
University of California, San Francisco · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8M
Regulation of Corneal Repair by MetalloproteinasesR01EY022739 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAN, MATILDA F · 2013 to 2017
$2.0M
NEI NIH HHS P30 EY002162NIDDK NIH HHS P30 DK063720NIH HHS EY002162NIH HHS EY022739Research to Prevent Blindness Physician-Scientist AwardResearch to Prevent Blindness Unrestricted grant to the UCSF Department of OphthalmologyThat Man May See Research Award
6 · The paper itself

Abstract

Mononuclear phagocytes (MP) have central importance in innate immunity, inflammation, and fibrosis. Recruited MPs, such as macrophages, are plastic cells and can switch from an inflammatory to a restorative phenotype during the healing process. However, the role of the MPs in corneal wound healing is not completely understood. The purpose of this study is to characterize the kinetics of recruited MPs and evaluate the role of macrophage metalloelastase (MMP12) in the healing process, using an in vivo corneal chemical injury model. Unwounded and wounded corneas of wild-type (WT) and

Indexed as

Burns, ChemicalCorneal InjuriesAnimalsCD11c AntigenCorneaMacrophagesMatrix Metalloproteinase 12MiceMice, Inbred C57BLCD11c AntigenMatrix Metalloproteinase 12corneal injurydendritic cellsmacrophagesMMP12monocytesmononuclear phagocytesmyeloid cells

Identifiers

PMID35269717
PMCPMC8910730
OpenAlexW4214521254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.