ArticleInternational journal of molecular sciences2022
Alternative Brain Slice-on-a-Chip for Organotypic Culture and Effective Fluorescence Injection Testing.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Toward functional precision oncology: organotypic brain slices in glioblastoma.Frontiers in oncology · 2026Review
- SliceChip: a benchtop fluidic platform for organotypic culture and serial assessment of human and rodent pancreatic slices.Lab on a chip · 2024Article
- Reproductive organ on-a-chip technologies and assessments of the fetal-maternal interface.Frontiers in lab on a chip technologies · 2024Article
- Future Trends in Biomaterials and Devices for Cells and Tissues.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Mouse brain slices are one of the most common models to study brain development and functioning, increasing the number of study models that integrate microfluidic systems for hippocampal slice cultures. This report presents an alternative brain slice-on-a-chip, integrating an injection system inside the chip to dispense a fluorescent dye for long-term monitoring. Hippocampal slices have been cultured inside these chips, observing fluorescence signals from living cells, maintaining the cytoarchitecture of the slices. Having fluorescence images of biological samples inside the chip demonstrates the effectiveness of the staining process using the injection method avoiding leaks or biological contamination. The technology developed in this study presents a significant improvement in the local administration of reagents within a brain slice-on-a-chip system, which could be a suitable option for organotypic cultures in a microfluidic chip acting as a highly effective bioreactor.
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Registered trials
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